943034-50-2

Basic information

• Product Name: 5-(2-chloroethyl)-2,3-dihydrobenzofuran
• Synonyms: 5-(2-chloroethyl)-2,3-dihydrobenzofuran;3-dihydro-;5-(2-chloroethyl)-2;Benzofuran, 5-(2-chloroethyl)-2,3-dihydro-;5-(2-chloroethyl)-2,3-dihydro-1-benzofuran
• CAS NO: 943034-50-2
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Mol File: 943034-50-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 284.4 °C at 760 mmHg
• Flash Point: 128.4 °C
• Appearance: /
• Density: 1.187 g/cm³
• Vapor Pressure: 0.00513mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(2-chloroethyl)-2,3-dihydrobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-chloroethyl)-2,3-dihydrobenzofuran(943034-50-2)
• EPA Substance Registry System: 5-(2-chloroethyl)-2,3-dihydrobenzofuran(943034-50-2)

Safety Data

• Hazardous Substances Data: 943034-50-2(Hazardous Substances Data)

Usage

General Description

5-(2-chloroethyl)-2,3-dihydrobenzofuran is a chemical compound with the molecular formula C10H11ClO. It is a derivative of benzofuran, a heterocyclic compound that contains a fused benzene and furan ring. The presence of the 2-chloroethyl group makes this compound potentially reactive, and it may be used in chemical reactions that involve substitution or alkylation. Benzofuran derivatives have been studied for their potential pharmaceutical applications, including as anticancer agents and as potential treatments for neurodegenerative diseases. The specific properties and potential applications of 5-(2-chloroethyl)-2,3-dihydrobenzofuran have not been extensively studied, so further research is needed to fully understand its potential uses and risks.

InChI:InChI=1/C10H11ClO/c11-5-3-8-1-2-10-9(7-8)4-6-12-10/h1-2,7H,3-6H2

Upstream product

• 64089-34-5 2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone 
• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 

Downstream Products

• 133099-07-7 (S)-darifenacin hydrobromide 
• 133099-04-4 darifenacin 
• 586346-94-3 darifenacin hydrochloride 
• 1072227-73-6 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 

Relevant articles and documents

PREPARATION OF DARIFENACIN AND ITS SALTS

Provided are various processes and compounds related to darifenacin and/or its salts. For example, there is provided a process for preparing a free base of darifenacin: Formula, or the salt thereof, the process including reacting 3-(S)-(cyanodiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl) ethyl] pyrrolidine of the Formula (IV), or a salt thereof: Formula (IV) with a base effective to convert the nitrile group of the compound of the Formula (IV) to the amide group of the darifenacin in an organic solvent, the reaction being carried out in the organic solvent, with a proviso that the solvent is not 2-methyl-butan-2-ol, and with further proviso that the reaction produces less than about 0.5 % of the compound of the Formula (Ic): Formula (Ic) in the reaction mass, as measured by HPLC. Various embodiments and variants are provided.

PROCESSES FOR PREPARING DARIFENACIN HYDROBROMIDE

The invention encompasses processes for the preparation of darifenacin hydrobromide.