87776-76-9 Usage
Description
2,3-Dihydro-5-benzofuranethanol is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique chemical structure, which consists of a benzofuran ring fused to a cyclohexane ring, with an alcohol group attached to the second carbon. This versatile molecule plays a significant role in the development of medications for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
2,3-Dihydro-5-benzofuranethanol is used as a key intermediate in the synthesis of Darifenacin (D193400, HBr), a medication specifically designed to treat urinary incontinence. 2,3-Dihydro-5-benzofuranethanol's unique structure allows it to effectively block the M3 muscarinic acetylcholine receptor, which is responsible for controlling the contraction of the bladder muscles. By inhibiting this receptor, Darifenacin helps to reduce the frequency and urgency of urination, providing relief to patients suffering from urinary incontinence.
In addition to its role in the synthesis of Darifenacin, 2,3-Dihydro-5-benzofuranethanol may also be utilized in the development of other pharmaceuticals with different therapeutic targets. Its unique chemical structure makes it a valuable building block for the creation of new drugs, potentially leading to the discovery of novel treatments for a wide range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 87776-76-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,7 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 87776-76:
(7*8)+(6*7)+(5*7)+(4*7)+(3*6)+(2*7)+(1*6)=199
199 % 10 = 9
So 87776-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O2/c11-5-3-8-1-2-10-9(7-8)4-6-12-10/h1-2,7,11H,3-6H2
87776-76-9Relevant articles and documents
Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers
Dachavaram, Soma Shekar,Penthala, Narsimha R.,Calahan, Julie L.,Munson, Eric J.,Crooks, Peter A.
, p. 6057 - 6062 (2018/09/06)
A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst selectively cleaves alcoholic TBDMS ethers in bis-TBDMS ethers containing both alcoholic and phenolic TBDMS ether moieties.
Novel preparation method of darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid
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, (2018/04/03)
The invention relates to a novel preparation method of a darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid. The method comprises the following steps: by taking 2,3-dihydrobenzofuran as aninitial raw material in the presence of a Lewis acid, carrying out a Friedel-Crafts acylation reaction with ethyl oxalyl monochloride so as to obtain a corresponding acyl compound; hydrolyzing to obtain alpha-ketonic acid sodium salt; reducing carbonyl into methylene by utilizing a Wolff-Kishner-HuangMinlong reaction, and acidizing, thereby obtaining the 2,3-dihydro-5-benzofuran acetic acid. The method disclosed by the invention is simple, convenient and safe, cheap and readily available in reactive raw materials and high in reaction yield and is particularly suitable for industrialized production of the 2,3-dihydro-5-benzofuran acetic acid.
OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES
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Page/Page column 29, (2008/12/08)
A quaternary ammonium compound of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.
