947275-36-7 Usage
General Description
(S)-1-Boc-4-benzylpiperazine-2-carbaldehyde is a chemical compound with a specific molecular structure that consists of a piperazine ring with a benzyl group and a carbaldehyde functional group. The compound also contains a Boc protecting group, which is commonly used in organic synthesis to protect amine groups. This chemical has potential applications in medicinal chemistry and drug discovery, as the piperazine moiety is present in many pharmaceuticals and can be modified to create new drug candidates. Additionally, the aldehyde group makes it versatile for further chemical reactions to synthesize complex molecules. Overall, this compound holds promise for use in the development of new pharmaceuticals and other chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 947275-36-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,2,7 and 5 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 947275-36:
(8*9)+(7*4)+(6*7)+(5*2)+(4*7)+(3*5)+(2*3)+(1*6)=207
207 % 10 = 7
So 947275-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O3/c1-17(2,3)22-16(21)19-10-9-18(12-15(19)13-20)11-14-7-5-4-6-8-14/h4-8,13,15H,9-12H2,1-3H3/t15-/m0/s1
947275-36-7Relevant articles and documents
Discovery of novel N-aryl piperazine CXCR4 antagonists
Zhao, Huanyu,Prosser, Anthony R.,Liotta, Dennis C.,Wilson, Lawrence J.
supporting information, p. 4950 - 4955 (2015/10/28)
A novel series of CXCR4 antagonists with substituted piperazines as benzimidazole replacements is described. These compounds showed micromolar to nanomolar potency in CXCR4-mediated functional and HIV assays, namely inhibition of X4 HIV-1IIIB virus in MAGI-CCR5/CXCR4 cells and inhibition of SDF-1 induced calcium release in Chem-1 cells. Preliminary SAR investigations led to the identification of a series of N-aryl piperazines as the most potent compounds. Results show SAR that indicates type and position of the aromatic ring, as well as type of linker and stereochemistry are significant for activity. Profiling of several lead compounds showed that one (49b) reduced susceptibility towards CYP450 and hERG, and the best overall profile when considering both SDF-1 and HIV potencies (6-20 nM).
