94739-24-9

Basic information

• Product Name: Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, ethyl ester
• Synonyms: Butanoic acid,2-[(2,3-dichlorophenyl)methylene]-3-oxo-,ethyl ester;2-[(2,3-dichlorophenyl)methylene]-3-oxobutanoic acid,ethyl ester;ethyl Z-2-acetyl-3-(2,3-dichlorophenyl)acrylate;ethyl 2-(2,3-dichlorophenylmethylene)acetoacetate
• CAS NO: 94739-24-9
• Molecular Formula: C13H12Cl2O3
• Molecular Weight: 287.142
• Mol File: 94739-24-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, ethyl ester(94739-24-9)
• EPA Substance Registry System: Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, ethyl ester(94739-24-9)

Safety Data

• Hazardous Substances Data: 94739-24-9(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 6334-18-5 2,3-dichlorobenzylaldehyde 

Downstream Products

• 72509-76-3 ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate 
• 96382-71-7 Dehydrofelodipine 
• 112080-24-7 Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 112080-30-5 Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 175688-78-5 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-ethyl ester 
• 106720-55-2 4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinecarboxylic acid ethyl ester 
• 108931-48-2 1,4-dihydro-2-methoxy-6-methyl-4-(2,3-dichlorophenyl)-5-pyrimidinecarboxylic acid, ethyl ester 
• 108932-05-4 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-6-methyl-5-pyrimidinecarboxylic acid, ethyl ester 

Relevant articles and documents

A new process for the preparation of felodipine (by machine translation)

The invention discloses a new process for the preparation of felodipine, including: 1) to acetyl acetic acid methyl ester as the raw material, to prepare the 3 - amino-crotonic acid methyl ester; 2) to 2, 3 - dichloro formaldehyde and acetyl acetic acid ethyl ester as the raw material, to prepare the 2, 3 - two chlorine asia phenmethyl acetyl ethyl acetate; 3) to 2, 3 - two chlorine asia phenmethyl acetyl ethyl acetate, 3 - amino-crotonic acid methyl ester as the raw material, prepare the felodipine. The invention of the preparation process of felodipine, intermediates for the preparation of 3 - amino-crotonic acid methyl ester having a melting point of 83 - 35 °C, far higher than the widely used of the intermediate 3 - amino-crotonic acid ethyl ester (33 - 35 °C), therefore the stability can be improved, convenient in a wider temperature conditions production and storage, is more favorable to the industrialized production and application. At the same time, the process high product yield, high purity, step is simple, easy to operate, and has good practicability. (by machine translation)

Catalytic effect of nanosized metal oxides on the knoevenagel reaction

The effect of nanosized metal oxides (Al, Mg, Cu, Ni oxides) on the synthesis of chalcones that are key intermediate in the synthesis of Nitrendipine and Felodipine drugs was examined.