947586-41-6

Basic information

• Product Name: (R)-methyl 2-(isopropylamino)butanoate
• Synonyms: (R)-methyl 2-(isopropylamino)butanoate;2-[(1-Methylethyl)amino]butanoic acid methyl ester hydrochloride;(R)-methyl 2-(isopropylamino)butanoate hydrochloride
• CAS NO: 947586-41-6
• Molecular Formula: C8H17NO2.HCl
• Molecular Weight: 195.69
• Mol File: 947586-41-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-methyl 2-(isopropylamino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-(isopropylamino)butanoate(947586-41-6)
• EPA Substance Registry System: (R)-methyl 2-(isopropylamino)butanoate(947586-41-6)

Safety Data

• Hazardous Substances Data: 947586-41-6(Hazardous Substances Data)

Usage

Description

(R)-methyl 2-(isopropylamino)butanoate, commonly known as levobupivacaine, is a chemical compound with the molecular formula C9H19NO2. It is a member of the amino ester class of local anesthetics and is considered less toxic than other similar compounds, making it a preferred choice for medical use.

Uses

Used in Medical Procedures:
(R)-methyl 2-(isopropylamino)butanoate is used as a local anesthetic for numbing specific areas of the body during medical procedures. It works by blocking nerve signals, providing pain relief and allowing for the safe and effective execution of surgeries or other interventions.
Used in Hospitals and Dental Offices:
(R)-methyl 2-(isopropylamino)butanoate is utilized in various medical settings, such as hospitals and dental offices, to provide pain relief and ensure patient comfort during surgical or dental procedures.
Available in Different Forms:
(R)-methyl 2-(isopropylamino)butanoate is available in various forms, including a solution for injection and a solution for infusion, catering to the diverse needs of medical professionals and patients.

Upstream product

• 85774-09-0 (R)-2-aminobutyric acid methyl ester hydrochloride 
• 67-64-1 acetone 
• 2623-91-8 (R)-2-aminobutyric acid 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 946161-16-6 methyl (2R)-2-[(2-chloro-5-nitropyrimidin-4-yl)(propan-2-yl)amino]butanoate 
• 889877-77-4 (7R)-2-chloro-7-ethyl-8-(propan-2-yl)-7,8-dihydropteridin-6(5H)-one 

Relevant articles and documents

A practical chromatography-free synthesis of a 5,6-dihydroimidazolo[1,5-f]pteridine derivative as a polo-like kinase-1 inhibitor

A practical chromatography-free synthesis of a potent polo-like kinase-1 inhibitor possessing a unique 5,6-dihydroimidazolo[1,5-f]pteridine structure has been developed. We showed that key cyanoimidazole ring formation could be conducted at benign temperature and obtained a chiral 5,6-dihydroimidazolo[1,5-f]pteridine derivative in good yield without epimerization. An aniline derivative containing a trans 1,4-cyclohexyl diamine structure was prepared by a synthesis that makes use of defined stereocenters of commercially available trans-cyclohexane-1,4-diamine via selective piperazine ring formation from a primary diamine. A coupling reaction of the 3-chloro-5,6-dihydroimidazolo[1,5-f]pteridine derivative and the aniline derivative in the endgame was closely investigated, and good yields were achieved both by palladium-catalyzed amination and acid-promoted coupling under benign reaction conditions. As a result of these investigations, the polo-like kinase-1 inhibitor was successfully obtained in a practical way without concern for generation/separation of stereoisomers.

TRIHYDROCHLORIDE FORMS OF A DIHYDROPTERIDINONE DERIVATIVE AND PROCESSES FOR PREPARATION

The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1- piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl