948044-23-3

Basic information

• Product Name: 4-[[(1,1’-dimethyl)dimethylsilyl]oxy]-α-phenyl-benzenemethanol
• Synonyms: 4-[[(1,1’-dimethyl)dimethylsilyl]oxy]-α-phenyl-benzenemethanol
• CAS NO: 948044-23-3
• Molecular Weight: 314.5
• Mol File: 948044-23-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[[(1,1’-dimethyl)dimethylsilyl]oxy]-α-phenyl-benzenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[(1,1’-dimethyl)dimethylsilyl]oxy]-α-phenyl-benzenemethanol(948044-23-3)
• EPA Substance Registry System: 4-[[(1,1’-dimethyl)dimethylsilyl]oxy]-α-phenyl-benzenemethanol(948044-23-3)

Safety Data

• Hazardous Substances Data: 948044-23-3(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 100-52-7 benzaldehyde 
• 120727-58-4 (4-((tert-butyldimethylsilyl)oxy)phenyl)(phenyl)methanone 

Downstream Products

• 833-39-6 4-hydroxy-benzhydrol 

Relevant articles and documents

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.