949568-31-4

Basic information

• Product Name: (R)-1,2-dichloro-4-(1-phenylallyl)benzene
• Synonyms: (R)-1,2-dichloro-4-(1-phenylallyl)benzene
• CAS NO: 949568-31-4
• Molecular Weight: 263.166
• Mol File: 949568-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-1,2-dichloro-4-(1-phenylallyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2-dichloro-4-(1-phenylallyl)benzene(949568-31-4)
• EPA Substance Registry System: (R)-1,2-dichloro-4-(1-phenylallyl)benzene(949568-31-4)

Safety Data

• Hazardous Substances Data: 949568-31-4(Hazardous Substances Data)

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 129140-95-0 C₉H₇BrCl₂ 
• 591-51-5 phenyllithium 
• 85217-69-2 cinnamyl methyl carbonate 
• 79175-35-2 3,4-dichlorophenylmagnesium bromide 
• 1136238-65-7 3-(3,4-dichlorophenyl)allyl methyl carbonate 
• 100-58-3 phenylmagnesium bromide 
• 87802-71-9 (E)-methyl cinnamyl carbonate 

Downstream Products

• 949568-47-2 (R,E)-methyl 4-(3,4-dichlorophenyl)-4-phenylbut-2-enoate 
• 304021-48-5 methyl (4R)-4-(3,4-dichlorophenyl)-4-phenylbutanoate 

Relevant articles and documents

Chiral Diarylmethanes via Copper-Catalyzed Asymmetric Allylic Arylation with Organolithium Compounds

A highly enantioselective copper/N-heterocyclic carbene catalyzed allylic arylation with organolithium compounds is presented. The use of commercial or readily prepared aryllithium reagents in the reaction with allyl bromides affords a variety of chiral diarylvinylmethanes, comprising a privileged structural motif in pharmaceuticals, in high yields with good to excellent regio- and enantioselectivities. The versatility of this new transformation is illustrated in the formal synthesis of the marketed drug tolterodine (Detrol).

Iridium-catalyzed asymmetric allylic substitution with aryl zinc reagents

Thanks to iridium catalysis, arylzinc reagents undergo regioselective allylic substitution with very high enantioselectivity, when associated with phosphoramidite ligands.