94977-52-3

Basic information

• Product Name: 2,4-DIFLUOROCINNAMIC ACID
• Synonyms: (2E)-3-(2,4-DIFLUOROPHENYL)-2-PROPENOIC ACID;3-(2,4-DIFLUOROPHENYL)-2-PROPENOIC ACID;3-(2,4-DIFLUOROPHENYL)ACRYLIC ACID;2,4-DIFLUOROCINNAMIC ACID;RARECHEM BK HW 0121;TRANS-2,4-DIFLUOROCINNAMIC ACID;trans-2,4-Difluorocinnamic;trans-2,4-Difluorocinnamic acid 98%
• CAS NO: 94977-52-3
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.14
• Product Categories: Cinnamic acid;C9;Carbonyl Compounds;Carboxylic Acids
• Mol File: 94977-52-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 216-218 °C(lit.)
• Boiling Point: 272 °C at 760 mmHg
• Flash Point: 118.3 °C
• Appearance: White to pale yellow powder
• Density: 1.3056 (estimate)
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.46
• PKA: 4.29±0.13(Predicted)
• CAS DataBase Reference: 2,4-DIFLUOROCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROCINNAMIC ACID(94977-52-3)
• EPA Substance Registry System: 2,4-DIFLUOROCINNAMIC ACID(94977-52-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-26/37/39
• WGK Germany: 3
• Hazardous Substances Data: 94977-52-3(Hazardous Substances Data)

Usage

Uses

trans-2,4-Difluorocinnamic acid may be used in chemical synthesis.

InChI:InChI=1/C10H8F3N/c11-10(12,13)9-5-1-3-8(7-9)4-2-6-14/h1,3,5,7H,2,4H2

Upstream product

• 452-76-6 2,4-difluorotoluene 
• 348-57-2 2,4-difluorobromobenzene 
• 79-10-7 acrylic acid 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 108-24-7 acetic anhydride 
• 4519-40-8 2,3-difluoroanilline 
• 5329-14-6 aminosulfonic acid 

Downstream Products

• 134672-70-1 3-(2,4-difluorophenyl)-propionic acid 
• 1391625-70-9 (3S,6S)-4-((E)-3-(2,4-difluorophenyl)acryloyl)-3,6-diisobutylpiperazin-2-one 
• 56772-92-0 muramyl dipeptide 
• 862283-61-2 (4S)-4-benzyl-3-[(2E)-3-(2,4-difluorophenyl)prop-2-enoyl]-1,3-oxazolidin-2-one 
• 862283-73-6 C₁₄H₁₄F₂O₃ 
• 1056139-71-9 tert-butyl (2E)-3-(2,4-difluorophenyl)prop-2-enoyl carbonate 
• 186758-21-4 methyl (2E)-3-(2,4-difluorophenyl)prop-2-enoate 
• 211568-09-1 (E)-3-(2,4-Difluoro-phenyl)-acryloyl azide 
• 695186-78-8 trans 3-(2,4-difluorophenyl)-2-propenoic acid chloride 
• 381229-49-8 (E)-1-(4-Acetyl-piperazin-1-yl)-3-(2,4-difluoro-phenyl)-propenone 

Relevant articles and documents

3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 3-aryl-5-substituted-2H-isoquinolin-1-one compounds that, inter alia, inhibit PARP (e.g., PARP1, TNKS1, TNKS2, etc.

Synthesis of Fluorine-Substituted Cinnamic Acids by Cross-Coupling of Fluorobenzenes with Acrylic Acid in the Presence of a Palladium Catalyst

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