950838-18-3

Basic information

• Product Name: (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one
• Synonyms: (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one
• CAS NO: 950838-18-3
• Molecular Weight: 192.214
• Mol File: 950838-18-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one(950838-18-3)
• EPA Substance Registry System: (4S,5R)-5-(hydroxymethyl)-4-phenyldihydrofuran-2(3H)-one(950838-18-3)

Safety Data

• Hazardous Substances Data: 950838-18-3(Hazardous Substances Data)

Upstream product

• 357675-06-0 methyl (R)-3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-phenylpropanoate 
• 67279-69-0 trans-4,5-dihydro-5-iodomethyl-4-phenyl-2(3H)-furanone 
• 5703-57-1 3-phenylpent-4-enoic acid 
• 104-54-1 3-Phenylpropenol 
• 112837-17-9 (R)-(+)-5-(hydroxymethyl)furan-2(5H)-one 
• 98-80-6 phenylboronic acid 
• 906098-15-5 methyl (3S,4R,5R,6S)-3-phenyl-4,5,6-tris(methoxymethoxy)-7-octenoate 
• 906098-14-4 methyl (2E,4R,5R,6S)-4,5,6-tris(methoxymethoxy)-2,7-octadienoate 
• 906098-18-8 (4S,5R)-4,5-dihydro-5-((1R,2S)-1,2-dihydroxybut-3-enyl)-4-phenyl-2(3H)-furanone 
• 81703-93-7 methyl (2E)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 
• 81703-94-8 methyl (2Z)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate 

Relevant articles and documents

Optically pure γ-butyrolactones and epoxy esters via two stereocentered HKR of 3-substituted epoxy esters: A formal synthesis of (-)-paroxetine, Ro 67-8867 and (+)-eldanolide

The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(iii)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted γ-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.

Stereoselective conjugate addition of aryl- And alkenylboronic acids to acyclic γ,δ-oxygen-substituted α,β-enoates

The substrate-controlled Rh1-catalyzed conjugate addition of aryl- and alkenylboronic acids to α,β-unsaturated esters which bear γ- and δ-oxygen substituents takes place in a highly anti diastereoselective fashion either when using γ-hydroxyl u