956434-21-2

Basic information

• Product Name: N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}propan-1-amine
• Synonyms: N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}propan-1-amine
• CAS NO: 956434-21-2
• Molecular Weight: 279.498
• Mol File: 956434-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}propan-1-amine(956434-21-2)
• EPA Substance Registry System: N-benzyl-2-{[tert-butyl(dimethyl)silyl]oxy}propan-1-amine(956434-21-2)

Safety Data

• Hazardous Substances Data: 956434-21-2(Hazardous Substances Data)

Upstream product

• 27159-32-6 3-benzylaminopropan-2-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-46-9 benzylamine 

Downstream Products

• 1423165-75-6 C₁₂H₁₇NO₃S 
• 1423165-91-6 C₁₂H₁₅NO₃S 
• 1423165-83-6 7-methyl-5-benzyl-[1,4,5]-oxathiazepane-4,4-dioxide 
• 1423165-99-4 2-benzyl-4-methyl-5-methylene-1,1-dioxo-isothiazolidin-4-ol 
• 1423166-07-7 1-(2-benzyl-1,1-dioxo-isothiazolidin-3-yl)-ethanone 
• 1423165-67-6 C₁₈H₃₁NO₃SSi 

Relevant articles and documents

Syntheses of five- and seven-membered ring sultam derivatives by Michael addition and Baylis-Hillman reactions

Five- and seven-membered sultam derivatives were conveniently synthesized via intra- or intermolecular Michael additions and an improved vinyl sulfonamide Baylis-Hillman reaction. Two different cyclization pathways were explored for the oxa-Michael reaction. A good solvent was discovered for an otherwise sluggish ketone-type Baylis-Hillman reaction in which vinyl sulfonamide ketones were used as the precursors. Furthermore, a strong base caused vinyl sulfonamide ketones to undergo 5-endo-trig intramolecular cyclizations, which are disfavored according to Baldwin's rule. Finally Baylis-Hillman reaction products were used as scaffolds for diversity-oriented sultam syntheses.