959237-34-4

Basic information

• Product Name: 2,4-Dichloro-7-iodoquinazoline
• Synonyms: 2,4-Dichloro-7-iodoquinazoline
• CAS NO: 959237-34-4
• Molecular Formula: C₈H₃Cl₂IN₂
• Molecular Weight: 324.932
• Mol File: 959237-34-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 279.2 °C at 760 mmHg
• Flash Point: 122.7 °C
• Appearance: /
• Density: 2.083 g/cm³
• Vapor Pressure: 0.00689mmHg at 25°C
• Refractive Index: 1.741
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,4-Dichloro-7-iodoquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloro-7-iodoquinazoline(959237-34-4)
• EPA Substance Registry System: 2,4-Dichloro-7-iodoquinazoline(959237-34-4)

Safety Data

• Hazardous Substances Data: 959237-34-4(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-7-iodoquinazoline is a chemical compound with the molecular formula C9H5Cl2IN2. It is a heterocyclic aromatic compound with a quinazoline ring structure, which contains two chlorine atoms and one iodine atom. 2,4-Dichloro-7-iodoquinazoline is used in the pharmaceutical industry as a building block for synthesizing various biologically active compounds. It has also been studied for its potential use in the development of new drugs. Additionally, it is used as a research tool in the study of organic chemistry and materials science. 2,4-Dichloro-7-iodoquinazoline has also been investigated for its pesticidal properties, with potential applications in agriculture. Overall, this compound has diverse uses and potential applications in various fields.

InChI:InChI=1/C8H3Cl2IN2/c9-7-5-2-1-4(11)3-6(5)12-8(10)13-7/h1-3H

Upstream product

• 626-01-7 3-Iodoaniline 
• 1039736-05-4 2-(ethylthio)-7-iodoquinazolin-4(3H)-one 
• 1039736-04-3 ethyl {[(3-iodophenyl)amino]carbonothioyl}carbamate 
• 959236-72-7 7-iodoquinazoline-2,4(1H,3H)-dione 

Downstream Products

• 1039736-06-5 N-(4-{[(2-chloro-7-iodoquinazolin-4-yl)amino]methyl}phenyl)-4-fluorobenzamide 
• 1039736-14-5 C₂₈H₂₇ClIN₅O 
• 1039733-08-8 N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1039733-00-0 N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1039735-10-8 N-[4-({[2-(dimethylamino)-7-vinylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1039733-10-2 N-[4-({[7-acetyl-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1039735-15-3 N-[4-({[2-(dimethylamino)-7-(hydroxymethyl)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide 
• 1039736-13-4 1-benzyl-N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]piperidine-4-carboxamide 
• 1039733-68-0 1-benzyl-N-[4-({[2-(dimethylamino)-7-vinylquinazolin-4-yl]amino}methyl)phenyl]piperidine-4-carboxamide 
• 1039733-05-5 N-[4-({[7-cyano-2-(dimethylamino)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride 
• 1039733-03-3 N-[4-({[2-(dimethylamino)-7-vinylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride 
• 1039733-04-4 N-[4-({[2-(dimethylamino)-7-ethylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride 
• 1039733-13-5 N-{4-[({2-(dimethylamino)-7-[(1Z)-prop-1-en-1-yl]quinazolin-4-yl}amino)methyl]phenyl}-4-fluorobenzamide hydrochloride 
• 1039733-11-3 N-[4-({[2-(dimethylamino)-7-(1-hydroxyethyl)quinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide hydrochloride 

Relevant articles and documents

Design and synthesis of novel diaminoquinazolines with in vivo efficacy for β-catenin/t-cell transcriptional factor 4 pathway inhibition

We are introducing a novel series of 2,4-diaminoquinazolines as β-catenin/Tcf4 inhibitors which were identified by ligand-based design. Here we elucidate the SAR of this series and explain how we were able to improve key molecular properties such as solubility and cLogP leading to compound 9. Analogue 9 exhibited better biological activity and improved physical and pharmacological properties relative to the HTS hit 49. Furthermore, 9 demonstrated good cell growth inhibition against several human colorectal cancer lines such as LoVo and HT29. In addition, treatment with compound 9 led to gene expression changes that overlapped significantly with the transcriptional profile resulting from the pathway inhibition by siRNA knockdown of β-catenin or Tcf4. Subsequently, 9 was tested for efficacy in a β-catenin/RKE-mouse xenograft, where it led to more then 50% decrease in tumor volume. 2009 American Chemical Society.