96-72-0

Basic information

• Product Name: 2-CHLORO-5-NITROBENZENESULFONAMIDE
• Synonyms: NSC 105711;2-CHLORO-5-NITROBENZENESULFONAMIDE;2-chloro-5-nitrobenzenesulphonamide;2-CHLORO-5-NITROBENZENESULFONAMIDE 98%;4-NITROCHLOROBENZENE-2-SULFONAMIDE;2-CHLORO-5-NITROBENZ;2-chloro-5-nitrobenzene-1-sulfonaMide
• CAS NO: 96-72-0
• Molecular Formula: C₆H₅ClN₂O₄S
• Molecular Weight: 236.63
• EINECS: 202-527-3
• Product Categories: Benzene derivates;Aromatics;Heterocycles
• Mol File: 96-72-0.mol
• Article Data: 32

Chemical Properties

• Melting Point: 180-183°C
• Boiling Point: 435.183 °C at 760 mmHg
• Flash Point: 216.991 °C
• Appearance: white solid
• Density: 1.664 g/cm³
• Vapor Pressure: 8.93E-08mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 2-CHLORO-5-NITROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-NITROBENZENESULFONAMIDE(96-72-0)
• EPA Substance Registry System: 2-CHLORO-5-NITROBENZENESULFONAMIDE(96-72-0)

Safety Data

• Hazardous Substances Data: 96-72-0(Hazardous Substances Data)

Usage

Description

2-Chloro-5-nitrobenzenesulfonamide, with the chemical formula C6H5ClN2O4S, is an organic compound characterized by a white solid appearance. It is known for its potential applications in various fields of organic synthesis, making it a valuable intermediate in the production of different chemical entities.

Uses

Used in Organic Synthesis:
2-Chloro-5-nitrobenzenesulfonamide is used as a synthetic intermediate for the production of various organic compounds. Its unique structure, featuring a chloro and nitro group attached to a benzene ring, allows it to participate in a range of chemical reactions, facilitating the synthesis of target molecules with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Chloro-5-nitrobenzenesulfonamide is utilized as a building block for the development of new drugs. Its reactivity and functional groups make it suitable for the synthesis of active pharmaceutical ingredients (APIs) that can address various medical conditions and therapeutic areas.
Used in Chemical Research:
2-Chloro-5-nitrobenzenesulfonamide also serves as a valuable research tool in the field of chemistry. It is employed in academic and industrial laboratories to study reaction mechanisms, explore new synthetic routes, and develop innovative methodologies for the preparation of complex organic molecules.
Used in Agrochemicals:
In the agrochemical industry, 2-Chloro-5-nitrobenzenesulfonamide is used as a precursor in the synthesis of various agrochemical products, such as pesticides and herbicides. Its contribution to the development of these products helps in enhancing crop protection and ensuring food security.
Used in Dye and Pigment Industry:
2-Chloro-5-nitrobenzenesulfonamide also finds application in the dye and pigment industry, where it is used as an intermediate for the synthesis of various dyes and pigments. These dyes and pigments are then utilized in a wide range of applications, including textiles, plastics, and printing inks, to impart color and enhance visual appeal.

InChI:InChI=1/C6H5ClN2O4S/c7-5-2-1-4(9(10)11)3-6(5)14(8,12)13/h1-3H,(H2,8,12,13)

Upstream product

• 96-73-1 2-chloro-5-nitro-benzenesulfonic acid 
• 946-30-5 2-chloro-5-nitrobenzenesulphonic acid sodium salt 
• 100-00-5 4-chlorobenzonitrile 
• 7790-94-5 chlorosulfonic acid 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 4533-95-3 5-nitro-2-chlorobenzenesulfonyl chloride 

Downstream Products

• 861062-46-6 2-(4-acetylamino-phenylsulfanyl)-5-nitro-benzenesulfonic acid amide 
• 127781-62-8 5-Nitro-2-piperidino-benzolsulfonamid 
• 127781-64-0 5-Nitro-2-(1-perhydroazocinyl)-benzolsulfonamid 
• 127781-63-9 5-Nitro-2-(1-perhydroazepinyl)-benzolsulfonamid 
• 16611-57-7 2-Dimethylamino-5-nitro-benzolsulfonamid 
• 127781-66-2 2-Diethylamino-5-nitro-benzolsulfonamid 
• 127781-65-1 2-(2-Methyl-1-piperidinyl)-5-nitro-benzolsulfonamid 
• 356041-30-0 2-(3'-methylphenylamino)-5-nitrobenzene sulfonamide 
• 54734-85-9 2-amino-5-nitrobenzenesulfonamide 
• 899790-35-3 2-(4-methylphenoxy)-5-nitrobenzenesulfonamide 
• 899790-25-1 2-(2,5-dimethylphenylamino)-5-nitrobenzenesulfonamide 
• 899790-24-0 2-(3-methyl-4-bromophenylamino)-5-nitrobenzenesulfonamide 
• 899790-17-1 2-(cyclohexylamino)-5-nitrobenzenesulfonamide 
• 899790-30-8 2-(4-methylphenylamino)-5-nitrobenzenesulfonamide 

Relevant articles and documents

Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome

Intracellular chloride concentration [Cl-]iis defective in several neurological disorders. In neurons, [Cl-]iis mainly regulated by the action of the Na+-K+-Cl-importer NKCC1 and the K+-Cl-exporter KCC2. Recently, we have reported the discovery of ARN23746 as the lead candidate of a novel class of selective inhibitors of NKCC1. Importantly, ARN23746 is able to rescue core symptoms of Down syndrome (DS) and autism in mouse models. Here, we describe the discovery and extensive characterization of this chemical class of selective NKCC1 inhibitors, with focus on ARN23746 and other promising derivatives. In particular, we present compound 40 ( ARN24092 ) as a backup/follow-up lead within vivoefficacy in a mouse model of DS. These results further strengthen the potential of this new class of compounds for the treatment of core symptoms of brain disorders characterized by the defective NKCC1/KCC2 expression ratio.

Research on the controllable degradation of: N -methylamido and dialkylamino substituted at the 5thposition of the benzene ring in chlorsulfuron in acidic soil

Owing to the lengthy residual problems associated with chlorsulfuron, metsulfuron-methyl, and ethametsulfuron, which prevents them from being used in the "annual multi-crop planting system", the application of these sulfonylurea herbicides (SU) has regrettably been terminated in China since 2014. In this field, we were the first to discover that the 5th position of the benzene ring in chlorsulfuron is a key point for influencing its degradation rate and the amino moiety at this position showed faster degradation rates and maintained their original potent bioactivity. In this study, we further elaborated on N-methylamido and dialkylamino substituents at the same position in chlorsulfuron to obtain 18 novel structures as M and N series. Their half-life degradation (DT50) values were faster, to varying degrees, than chlorsulfuron in acidic soil. It was found that most of the titled structures also retained their potent herbicidal activity and the crop safety of the M series towards corn greatly increased. Based on these data, a comprehensive graph describing the structure/degradation relationship was established first. Relating to the new molecules, their herbicidal activity (A), degradation rates (D), and crop safety (S) relationship were correlated and we used this approach to predict and explore the most preferable molecule, which coincided to the corresponding experimental data. The new concept of controllable degradation will provide us with more insight when searching for new ecological bioactive molecules in the future.

METHODS AND COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS AND VIRAL INFECTIONS

The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TPβ) receptor subtype.