960356-44-9

Basic information

• Product Name: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
• Synonyms: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt
• CAS NO: 960356-44-9
• Molecular Weight: 531.657
• Mol File: 960356-44-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt(960356-44-9)
• EPA Substance Registry System: 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic acid ammonium salt(960356-44-9)

Safety Data

• Hazardous Substances Data: 960356-44-9(Hazardous Substances Data)

Upstream product

• 144701-48-4 telmisatran 
• 144702-27-2 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl 
• 528560-93-2 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 

Downstream Products

• 144701-48-4 telmisatran 

Relevant articles and documents

4 ′ - [[2 a-n - (1 - methylbenzimidazole -2 - yl) - benzimidazole -1 - yl methyl propyl -4 - -6 -] - methyl] - biphenyl carboxylic acid ammonium salt crystals -2 - (by machine translation)

PROBLEM TO BE SOLVED: To provide a method for obtaining 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazole-1-yl]-methyl]-biphenyl-2-carboxylic acid with high purity.SOLUTION: A method for purifying a compound of formula (1) below includes: a dissolution process of dissolving a crude substance of 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole-1-yl]-methyl]-biphenyl-2-carboxylic acid in a mixed solvent of water and a 2-12C alcohol by adding 2.0 to 30.0 mol of ammonia per mol of a composition of formula (1) below; a crystallization process of depositing an ammonium salt of the composition of formula (1) below by discharging ammonia from the solvent obtained in the process; and a process of separating and drying the ammonium salt.

METHOD FOR PRODUCING AMMONIUM SALT OF TELMISARTAN

PROBLEM TO BE SOLVED: To provide a method for producing an ammonium salt of telmisartan effective as a hypotensive agent with high purity. SOLUTION: The method for producing an ammonium salt of telmisartan comprises a dissolution step of dissolving a crude body of telmisartan by adding, in a mixed solvent of water, a 2-12C alcohol and ethyl acetate, ammonia in an amount of 2.0 to 30.0 mol based on 1 mol of the telmisartan at 0 to 30°C to form an ammonium salt of telmisartan and a crystallization step of depositing the ammonium salt of telmisartan from the solution produced in the dissolution step at 0 to 30°C and achieves reduction of specific impurities C and D. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT