96155-82-7

Basic information

• Product Name: ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER
• Synonyms: ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER;Napthaleneacetic acid,alpha-bromo-ethyl ester;a-Bromo-1-naphthalen;ethyl 2-bromo-2-(naphthalen-1-yl)acetate
• CAS NO: 96155-82-7
• Molecular Formula: C₁₄H₁₃BrO₂
• Molecular Weight: 293.16
• Mol File: 96155-82-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER(96155-82-7)
• EPA Substance Registry System: ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER(96155-82-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 96155-82-7(Hazardous Substances Data)

Usage

Description

ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER is a chemical compound that serves as an ethyl ester of alpha-bromo-1-naphthaleneacetic acid. It is recognized for its role as a synthetic plant growth regulator and a potent inhibitor of auxin-induced plant elongation. ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER holds significant value in both agricultural and pharmaceutical research and development.

Uses

Used in Agricultural Industry:
ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER is used as a plant growth regulator for controlling the growth and development of plants. Its application in agriculture helps optimize crop yield and quality by managing plant size and shape.
Used in Pharmaceutical Industry:
ALPHA-BROMO-1-NAPHTHALENEACETIC ACID ETHYL ESTER is utilized for its potential therapeutic applications. Its role as a chemical compound in the pharmaceutical field opens up possibilities for the development of new drugs and treatments.

Upstream product

• 86-87-3 naphth-1-yl acetic acid 
• 64-17-5 ethanol 
• 132-75-2 naphthalen-1-ylacetonitrile 
• 2122-70-5 ethyl 2-(1-naphthyl)acetate 

Downstream Products

• 1345693-45-9 ethyl 2-(dibenzylamino)-2-(naphthalen-1-yl)acetate 
• 1345693-74-4 ethyl 2-(dibenzylamino)-2-(naphthalen-1-yl)butanoate 
• 1345693-52-8 N,N-dibenzyl-2-((tert-butyl)dimethylsilyloxy)-2-ethoxy-1-(naphthalen-1-yl)ethenamine 
• 1287678-26-5 C₃₁H₂₆ClN₃O₂S 
• 1287678-24-3 C₃₁H₂₆ClN₃O₂S 
• 1287678-22-1 C₃₁H₂₅ClN₄O₃S 
• 1287678-20-9 C₃₀H₂₄ClN₃O₃S 
• 1287678-19-6 C₃₀H₃₀ClN₃O₂S 
• 1287678-18-5 C₃₁H₂₃ClN₄O₂S 
• 1287678-17-4 C₃₀H₂₄ClN₃O₂S 
• 1287678-16-3 C₃₀H₂₄ClN₃O₂S 
• 1287678-14-1 C₃₂H₃₆ClN₃O₂S 
• 1287678-11-8 C₂₉H₂₂ClN₃O₂S 
• 1287678-10-7 C₂₉H₂₂ClN₃O₂S 

Relevant articles and documents

AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS

The present invention relates to derivatives of formula (I) which bind to the liver X receptor (LXRα and/or LXRβ) and act preferably as inverse agonists of LXR.

Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells

We present the synthesis and biological evaluation of a collection of s-triazine derivatives as a novel scaffold of compounds with the capability to inhibit the PGE2 production in LPS-induced RAW 264.7 macrophage cells. A total of 12 derivatives were synthesized and assayed for PGE2 reduction at 10 μM concentration. Two compounds (7b and 7i) exhibiting >90% inhibition of PGE2 production were found to have IC50 values of 5.76 and 5.52 μM, respectively. They were counter screened for inhibition on COX-2 activity in a cell free assay. Specifically, compound 7i (R1 = 4-Bn-Ph, R2 = Cl, R3 = Ph, R5 = CO2Me) was highly active in cells while maintaining little COX-2 inhibition (～0% at 10 μM). Molecular docking study provides the possibility that compound 7i could inhibit PGE2 production by blocking the PGH2 binding site of mPGES-1 instead of COX-2 enzyme. Based on this result, our synthetic efforts will focus on intensive structure-activity relationship (SAR) study of s-triazine scaffold to discovery a potential PGE2 synthesis inhibitor.

Generation of iminyl copper species from α-azido carbonyl compounds and their catalytic C-C bond cleavage under an oxygen atmosphere

Figure presented A copper-catalyzed reaction of α-azidocarbonyl compounds under an oxygen atmosphere is reported where nitriles are formed via C-C bond cleavage of a transient iminyl copper intermediate. The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from α-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O2 was found to be incorporated into the β-carbon fragment as a carboxylic acid.