96551-29-0Relevant articles and documents
PROCESS FOR THE ISOLATION OF GANCICLOVIR INTERMEDIATE
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Page/Page column 10, (2011/10/10)
The present invention relates to process for isolation of ganciclovir intermediate. The present invention also provides a novel crystalline forms of ganciclovir, processes for their preparation and pharmaceutical composition comprising them. Thus, for example, to a mixture containing N-7 and N-9 isomer was added acetic acid and acetonitrile at 25 to 300C to obtain a mass having a pH of 4.0 to 5.0, the reaction mass was cooled to -5 to -100C and stirred for 3 hours at -5 to -100C, filtered, washed with chilled acetonitrile and dried at 600C for 4 hours to give N2-acetyl-9-(l,3-diacetoxy-2- propoxymethyl) guanine.