96803-30-4

Basic information

• Product Name: 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE
• Synonyms: 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE;AKOS 92034;Benzo[b]thiophene-5-ethanol;2-(benzo[b]thiophen-5-yl)ethanol;2-(1-benzothiophen-5-yl)ethan-1-ol
• CAS NO: 96803-30-4
• Molecular Formula: C₁₀H₁₀OS
• Molecular Weight: 178.25
• Mol File: 96803-30-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 56-57 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 327.322 °C at 760 mmHg
• Flash Point: 151.759 °C
• Appearance: /
• Density: 1.243 g/cm³
• PKA: 14.84±0.10(Predicted)
• CAS DataBase Reference: 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE(96803-30-4)
• EPA Substance Registry System: 5-(2-HYDROXYETHYL)BENZO(B)THIOPHENE(96803-30-4)

Safety Data

• Hazardous Substances Data: 96803-30-4(Hazardous Substances Data)

Usage

Uses

2-(Benzo[b]thiophen-5-yl)ethanol is derived from 5-Bromobenzo[b]thiophene (B680425), which is used as a reactant in the preparation of 4-aminoquinolines and tetraoxanes displaying antimalarial activity.

Upstream product

• 17381-54-3 (1-benzothiophen-5-yl)acetic acid 
• 98820-66-7 benzothiophene-5-acetic acid ethyl ester 
• 75-21-8 oxirane 
• 4923-87-9 5-bromobenzo[b]thiophene 
• 74-88-4 methyl iodide 
• 17381-51-0 (1-benzothiophen-5-yl)acetonitrile 
• 10133-22-9 5-bromomethyl-benzo[b]thiophene 

Downstream Products

• 519188-42-2 3-(2-(1-benzothiophen-5-yl)ethoxy)propionic acid 
• 519188-55-7 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propionyl)azetidin-3-ol 

Relevant articles and documents

2-(1-Benzothiophen-5-yl) production of ethanol

PROBLEM TO BE SOLVED: To provide an excellent production method for 2-(1-benzothiophen-5-yl)ethanol. SOLUTION: There is provided a method for production of 2-(1-benzothiophen-5-yl)ethanol comprising esterifying (1-benzothiophen-5-yl)acetic acid, and performing the reductive reaction of the resultant ester using a boron hydride complex compound in the presence or absence of a metal halide. This is useful as a production method for 2-(1-benzothiophen-5-yl)ethanol, safe for human bodies and environmentally friendly. COPYRIGHT: (C)2011,JPOandINPIT

PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)- ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF

A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1- benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.

Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor

Novel 2-sulfamoylbenzo[b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.