97060-28-1

Basic information

• Product Name: (E)-1-(4-bromophenyl)-3-hydroxybutan-1-one
• Synonyms: (E)-1-(4-bromophenyl)-3-hydroxybutan-1-one
• CAS NO: 97060-28-1
• Molecular Weight: 225.085
• Mol File: 97060-28-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-bromophenyl)-3-hydroxybutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-bromophenyl)-3-hydroxybutan-1-one(97060-28-1)
• EPA Substance Registry System: (E)-1-(4-bromophenyl)-3-hydroxybutan-1-one(97060-28-1)

Safety Data

• Hazardous Substances Data: 97060-28-1(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 625-35-4 trans-chrotonyl chloride 
• 122969-81-7 1-(4-bromophenyl)-3-hydroxybutan-1-one 
• 24850-33-7 allyltributylstanane 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 75-07-0 acetaldehyde 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 
• 99-73-0 para-bromophenacyl bromide 
• 2928-58-7 (2-oxo-2-p-bromophenylethyl)triphenylphosphonium bromide 
• 4981-64-0 1-(4-bromophenyl)-1-butanone 

Downstream Products

• 122969-13-5 (3RS,1'RS)-3-(3'-(4-bromophenyl)1'-methyl-3'-oxopropyl)-1-methyl-2-pyrrolidinone 
• 122968-94-9 (E,3RS,1'-SR)-3-(1'-(4-bromophenyl)-1'-hydroxy-2'-butenyl)-1-methyl-2-pyrrolidinone 
• 122968-93-8 (E,3RS,1'RS)-3-(1'-(4-bromophenyl)-1'-hydroxy-2'-butenyl)-1-methyl-2-pyrrolidinone 
• 97060-62-3 3-<4-(p-bromophenyl)-4-oxo-2-butyl>-N-methylpyrrolidone 
• 97060-61-2 3-<1-(p-bromophenyl)-1-hydroxy-2-butenyl>-N-methylpyrrolidone 
• 164595-90-8 (2'RS,3'RS)- and (2'RS,3'SR)-1-(5'-(4-bromophenyl)-2',3'-dimethyl-1',5'-dioxopentyl)pyrrolidine 
• 97060-59-8 (E,2'RS,3'RS)- and (E,2'RS,3'SR)-1-(3'-(4-bromophenyl)-3'-hydroxy-2'-methyl-1'-oxo-4'-hexenyl)pyrrolidine 

Relevant articles and documents

Enantioselective N -Alkylation of Nitroindoles under Phase-Transfer Catalysis

An asymmetric phase-transfer-catalyzed N -alkylation of substituted indoles with various Michael acceptors was studied. Acidities of nitroindoles were determined in acetonitrile by UV-Vis spectrophotometric titration. There was essentially no correlation between acidity and reactivity in the aza-Michael reaction. The position of the nitro group on the indole ring was essential to control the stereoselectivity of the reaction. Michael adducts were obtained in high yields and moderate enantioselectivities in the reaction between 4-nitroindole and various Michael acceptors in the presence of cinchona alkaloid based phase-transfer catalysts. In addition to outlining the scope and limitations of the method, the geometries of the transition states of the reaction were calculated.

Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes

A general, efficient and economic palladium-catalyzed dehydrogenation to form enones or enals has been developed. The approach possesses extremely broad substrate scope including various linear or cyclic saturated ketones and aldehydes. The protocol is ligand-free, and molecular oxygen is used as the sole clean oxidant in the reaction. Due to mild reaction conditions, good functional group compatibility, and versatile utilities of enones and enals, the method can be applied in the late-stage synthesis of natural products, pharmaceuticals and fine chemicals. (Figure presented.).

Can simple enones be useful partners for the catalytic stereoselective alkylation of indoles?

A new catalytic system for the first example of enantioselective Friedel-Crafts-type (FC) addition of indoles to simple enones is described. The use of an equimolar amount of chiral [Al(salen)Cl] and 2,6-lutidine (10 mol%) was found to be effective in pro