97070-79-6

Basic information

• Product Name: (R)-(+)-4-CHLOROMANDELONITRILE
• Synonyms: (R)-(+)-4-CHLOROMANDELONITRILE;(2R)-2-(4-chlorophenyl)-2-hydroxyacetonitrile
• CAS NO: 97070-79-6
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• Product Categories: Chiral Building Blocks;Cyanides/Nitriles;Organic Building Blocks
• Mol File: 97070-79-6.mol
• Article Data: 42

Chemical Properties

• Melting Point: 70-74 °C(lit.)
• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 149.8°C
• Appearance: /
• Density: 1.331g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• PKA: 10.30±0.20(Predicted)
• CAS DataBase Reference: (R)-(+)-4-CHLOROMANDELONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-4-CHLOROMANDELONITRILE(97070-79-6)
• EPA Substance Registry System: (R)-(+)-4-CHLOROMANDELONITRILE(97070-79-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 97070-79-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6ClNO/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4,8,11H/t8-/m0/s1

Upstream product

• 74-90-8 hydrogen cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 139765-19-8 (R,S)-α-[(tert-butyldimethylsilyl)oxy]-α-(4-chlorophenyl)acetonitrile 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 412296-10-7 (R)-2-(4-chlorophenyl)-2-(trimethylsiloxy)acetonitrile 
• 13312-83-9 4-chloromandelonitrile 
• 773837-37-9 sodium cyanide 
• 108-05-4 vinyl acetate 
• 99074-23-4 cyano(4-chlorophenyl)methyl acetate 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 66985-46-4 (+/-)-2-(4-chlorophenyl)-2-(trimethylsiloxy)-acetonitrile 
• 873-76-7 para-Chlorobenzyl alcohol 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 492-86-4 (R)-4-chloro-α-hydroxy-benzeneacetic acid 
• 126641-86-9 (R)-acetoxy(4-chlorophenyl)acetonitrile 
• 128535-90-0 (R)-2-amino-1-(4-chlorophenyl)ethanol 
• 136983-95-4 (S)-2-acetyloxy-2-(4-chlorophenyl)acetonitrile 
• 865357-16-0 (R)-2-(benzoyloxy)-2-(4-chlorophenyl)acetonitrile 
• 76496-63-4 (S)-4-chloro-α-hydroxy-benzeneacetic acid 

Relevant articles and documents

Supported Ionic Liquid-Like Phases (SILLPs) as Immobilised Catalysts for the Multistep and Multicatalytic Continuous Flow Synthesis of Chiral Cyanohydrins

Supported Ionic Liquid-Like Phases have been found to be efficient organocatalysts for the synthesis of cyanohydrin esters under solvent-free conditions by an “electrophile-nucleophile dual activation” based on hydrogen bond formation. The combination of

Preparation of chitosan-supported urea materials and their application in some organocatalytic procedures

An efficient and mild procedure was developed for the preparation of three chitosan-supported ureas containing electron-withdrawing groups. These catalysts were characterized and employed as organocatalysts in different transformations, including the enan

Enantioselective cyanosilylation of aldehydes catalyzed by a multistereogenic salen-Mn(III) complex with a rotatable benzylic group as a helping hand

A multistereogenic salen-Mn(iii) complex bearing an aromatic pocket and two benzylic groups as helping hands was found to be efficient in the catalysis of asymmetric cyanosilylation. The salen-Mn catalyst partially mimics the functions of biocatalysts by