980-71-2 Usage
Description
Brompheniramine hydrogen maleate, also known as brompheniramine maleate, is a first-generation antihistamine of the propylamine class. It is the maleic acid salt of brompheniramine and is chemically represented as (+)2-[p-bromo-α-[2-(dimethylamino)ethyl]benzyl]pyridine bimaleate. Brompheniramine hydrogen maleate is a white solid that antagonizes histamine H1 receptors (Ki = 6.06 nM) and also inhibits the reuptake of serotonin and norepinephrine. It differs from chlorpheniramine by the substitution of a bromine atom for the chlorine atom, and its actions and uses are similar to those of chlorpheniramine. It has a half-life of 25 hours, which is almost twice that of chlorpheniramine.
Uses
Used in Pharmaceutical Industry:
Brompheniramine hydrogen maleate is used as an antihistamine for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It functions by antagonizing histamine H1 receptors, providing relief from allergy symptoms.
Used in Combination Medications:
Brompheniramine hydrogen maleate is used in combination with other medications to treat various conditions. Some of the combination medications include Bromfed, Dimetane, Dimetapp, Drixomed, Histatab, and Nasahist. These combinations aim to provide additional therapeutic benefits and address multiple symptoms simultaneously.
Used as a Serotonin Reuptake Inhibitor:
Brompheniramine hydrogen maleate also acts as an inhibitor of serotonin reuptake, which can contribute to its therapeutic effects in certain conditions. This dual action of being an antihistamine and a serotonin reuptake inhibitor makes it a versatile compound in the treatment of various medical conditions.
Originator
Dimetane,Robins,US,1957
Manufacturing Process
Initially, 4-bromobenzyl-cyanide is reacted with sodium amide and 2-
chloropyridine to give bromophenyl-pyridyl acetonitrile. This is then reacted
with sodium amide then dimethyl amino ethyl chloride to give 4-bromophenyldimethylaminoethyl-
pyridyl acetonitrile. This intermediate is then hydrolyzed
and decarboxylated to bromphenirame using 80% H2SO4 at 140°-150°C for
24 hours. The brompheniramine maleate may be made by reaction with
maleic acid in ethanol followed by recrystallization from pentanol.
Side effects
The side effects of this
medication are similar to other classes of sedative antihistamines. Some medications
include parabens. Patients sensitive to parabens may develop a sensitivity
reaction.
Check Digit Verification of cas no
The CAS Registry Mumber 980-71-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,8 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 980-71:
(5*9)+(4*8)+(3*0)+(2*7)+(1*1)=92
92 % 10 = 2
So 980-71-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
