2391-03-9 Usage
Description
DEXBROMPHENIRAMINE MALEATE is the maleic acid salt of the (pharmacologically active) (S)-(+)-enantiomer of brompheniramine, a histamine H1 receptor antagonist. It is predominantly found in the dextro isomer form, known as dexbrompheniraminemaleate (D-isomer), and is of comparable potency to its chlorine derivative. DEXBROMPHENIRAMINE MALEATE is used for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.
Uses
Used in Pharmaceutical Industry:
DEXBROMPHENIRAMINE MALEATE is used as an antihistaminic agent for the symptomatic relief of allergic conditions. It works by blocking the action of histamine, a substance released during an allergic reaction, thus providing relief from symptoms such as sneezing, itching, and runny nose.
Used in Allergy Treatment:
DEXBROMPHENIRAMINE MALEATE is used as a treatment for allergic conditions, particularly for the relief of symptoms associated with rhinitis and conjunctivitis. It helps to alleviate the discomfort and inflammation caused by allergens, providing temporary relief for those suffering from these conditions.
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 2391-03-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,9 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2391-03:
(6*2)+(5*3)+(4*9)+(3*1)+(2*0)+(1*3)=69
69 % 10 = 9
So 2391-03-9 is a valid CAS Registry Number.
InChI:InChI=1/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
2391-03-9Relevant articles and documents
Preparation of a β-cyclodextrin-based open-tubular capillary electrochromatography column and application for enantioseparations of ten basic drugs
Fang, Linlin,Yu, Jia,Jiang, Zhen,Guo, Xingjie
, (2016/01/29)
An open-tubular capillary electrochromatography column was prepared by chemically immobilized β-cyclodextrin modified gold nanoparticles onto new surface with the pre-derivatization of (3-mercaptopropyl)-trimethoxysilane. The synthesized nanoparticles and the prepared column were characterized by transmission electron microscopy, scanning electron microscopy, infrared spectroscopy and ultraviolet visible spectroscopy. When the column was employed as the chiral stationary phase, no enantioselectivity was observed for ten model basic drugs. So β-cyclodextrin was added to the background electrolyte as chiral additive to expect a possible synergistic effect occurring and resulting in a better separation. Fortunately, significant improvement in enantioselectivity was obtained for ten pairs of drug enantiomers. Then, the effects of β-cyclodextrin concentration and background electrolyte pH on the chiral separation were investigated. With the developed separation mode, all the enantiomers (except for venlafaxine) were baseline separated in resolutions of 4.49, 1.68, 1.88, 1.57, 2.52, 2.33, 3.24, 1.63 and 3.90 for zopiclone, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, sibutramine hydrochloride and terbutaline sulfate, respectively. Further, the possible separation mechanism involved was discussed.
