98586-21-1

Basic information

• Product Name: 3,3'-DIFLUOROBENZHYDROL
• Synonyms: 3,3'-DIFLUOROBENZHYDROL
• CAS NO: 98586-21-1
• Molecular Formula: C₁₃H₁₀F₂O
• Molecular Weight: 220.21
• Mol File: 98586-21-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,3'-DIFLUOROBENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-DIFLUOROBENZHYDROL(98586-21-1)
• EPA Substance Registry System: 3,3'-DIFLUOROBENZHYDROL(98586-21-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 98586-21-1(Hazardous Substances Data)

Upstream product

• 107337-71-3 3-fluorophenyllithium 
• 456-48-4 3-Fluorobenzaldehyde 
• 1073-06-9 3-fluorobromobenzene 
• 1224964-62-8 3,3'-difluorobenzhydryl tosylate 
• 109-94-4 formic acid ethyl ester 
• 345-70-0 3,3'-difluorobenzophenone 

Downstream Products

• 187842-09-7 3,3’-(chloromethylene)bis(fluorobenzene) 
• 345-70-0 3,3'-difluorobenzophenone 
• 872053-62-8 9-(bis(3-fluorophenyl)methylene)-9H-fluorene 
• 1207274-75-6 carbonic acid (R)-1-aza-bicyclo[2.2.2]oct-3-yl ester bis-(3-fluoro-phenyl)-methyl ester 
• 10605-49-9 1,1-bis(3-fluorophenyl)ethylene 
• 117082-80-1 C₁₅H₁₂F₂O₂S 
• 117082-83-4 2-((bis(3-fluorophenyl)methyl)thio)acetamide 
• 117082-77-6 2-((bis(3-fluorophenyl)methyl)sulfinyl)acetamide 
• 1404054-68-7 (R)-3-((bis(3-fluorophenyl)methoxy)carbonothioylamino)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride 
• 1404054-53-0 (R)-3-((bis(3-fluorophenyl)methoxy)carbonyl amino)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1404054-16-5 (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate 
• 1404054-69-8 (R)-bis(3-fluorophenyl)methyl 1-benzylpyrrolidin-3-ylcarbamate 
• 1404054-67-6 (R)-O-[bis(3-fluorophenyl)methyl] quinuclidin-3-ylcarbamothioate 
• 1404054-89-2 1-benzyl-3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-azoniabicyclo[2.2.2]octane bromide 

Relevant articles and documents

Temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides

The temperature-controlled divergent synthesis of 4-alkoxy- or 4-alkenyl-chromanes via inverse electron-demand cycloaddition with in situ generated ortho-quinone methides under identical reaction conditions except for thermal condition has been developed. At room temperature, the reaction generated 4-methoxychromanes, whereas the reaction performed at room temperature to 100 °C gave 4-alkenylchromanes. Trifluoromethanesulfonic acid was efficiently suitable in the reaction to give the 4-substituted chromanes. This divergent synthetic strategy exhibits a new method giving carbon–carbon or carbon–oxygen bond by controlling the reaction temperature.

Kinetics of the solvolyses of fluoro-substituted benzhydryl derivatives: Reference electrofuges for the development of a comprehensive nucleofugality scale

A series of m-fluoro-substituted benzhydryl chloridcjs, bromides, mesylates and Losylates 1-X to 5-X were prepared and subjected to solvolysis reactions in various solvents. The observed first-order rate constants ks(25 °C) were found to follow the correlation equation log ks(25 °C) = Sf(Nf + Ef), which allowed us to determine the electrofugalily parameters Ef for these destabilized benzhydrylium cations and the nucleofugality parameters Nf, S f for a series of leaving group/ solvent combinations.

MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF

Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.