98769-84-7

Basic information

• Product Name: Reboxetine mesylate
• Synonyms: (2R)-REL-2-[(R)-(2-ETHOXYPHENOXY)PHENYLMETHYL]MORPHOLINE MESYLATE;EDRONAX;REBOXETINE MESILATE;REBOXETIN MESYLATE;VESTRA;REBOXETINE MESYLATE HYDRATE;(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine;PNU 155950E
• CAS NO: 98769-84-7
• Molecular Formula: CH₄O₃S*C₁₉H₂₃NO₃
• Molecular Weight: 409.5
• Product Categories: Active Pharmaceutical Ingredients;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical Intermediates;Aromatics;Chiral Reagents;Inhibitors
• Mol File: 98769-84-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 170-171°C
• Boiling Point: 443.7 °C at 760 mmHg
• Flash Point: 188.2 °C
• Appearance: tan or off-white/amorphous semi-solid
• Vapor Pressure: 4.54E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: ~8 mg/mL at ≤60 °C
• CAS DataBase Reference: Reboxetine mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: Reboxetine mesylate(98769-84-7)
• EPA Substance Registry System: Reboxetine mesylate(98769-84-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 98769-84-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 98769-84-7 differently. You can refer to the following data:
1. A selective noradrenaline reuptake inhibitor. Antidepressant.
2. Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:to study its effects on the surge of dopamine in the cortex of mice brainto study its anti-immobility effects on the behavior of miceto analyze its effects on the probabilistic reversal learning task in rodents

Biochem/physiol Actions

Reboxetine?exhibits anti-depressant activity.

InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)/t18-,19-;/m0./s1

Upstream product

• 75-75-2 methanesulfonic acid 
• 71620-89-8 reboxetine 
• 71620-89-8 (2RS,3SR)-2-<α-(2-ethoxyphenoxy)benzyl>morpholine 
• 98769-69-8 (2RS,3SR)-3-(2-ethoxyphenoxy)-1,2-dihydroxy-3-phenylpropane 
• 40641-81-4 trans-2,3-epoxy-3-phenylpropan-1-ol 
• 104-54-1 3-Phenylpropenol 
• 93851-63-9 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 93886-32-9 (2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 98769-72-3 (2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 94-71-3 2-Ethoxyphenol 

Relevant articles and documents

The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate

The Pfizer Green Chemistry metrics program is described and exemplified with a case history involving the synthesis of (S,S)-reboxetine succinate. The initial route used a classical resolution approach and generated high levels of waste. This route was replaced by an enantiospecific synthesis which used Sharpless epoxidation chemistry, an enzymatic process to selectively protect a primary alcohol and a new efficient method of chiral morpholine construction as key steps. These improvements reduced the levels of waste produced by the synthesis by more than 90%. Detailed metrics starting from a common starting material (trans-cinnamyl alcohol) for all routes of synthesis are presented.

Configurational studies on 2-[α-(2-ethoxyphenoxy)benzyl]morpholine FCE 20124

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