71620-89-8 Usage
Description
Reboxetine mesylate, also known as Edronax, is a pharmaceutical compound that belongs to the class of selective noradrenaline reuptake inhibitors (NRIs). It is primarily used as an antidepressant, working by selectively blocking the reuptake of noradrenaline in the brain, thereby increasing its levels and enhancing mood. Reboxetine mesylate is characterized by its effectiveness in treating major depressive disorder and its potential role in biological studies related to monoaminergic neurotransmission.
Uses
Used in Pharmaceutical Industry:
Reboxetine mesylate is used as an antidepressant for the treatment of major depressive disorder. It functions as a selective noradrenaline reuptake inhibitor, increasing the levels of noradrenaline in the brain and improving mood.
Used in Research and Development:
In the field of biological research, Reboxetine mesylate is used to study the involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test. This application aids in understanding the underlying mechanisms of antidepressant effects and contributes to the development of novel therapeutic strategies for depression.
Brand name:
Edronax (Pharmacia & Upjohn) is the brand name under which Reboxetine mesylate is marketed and distributed for its antidepressant use.
Biological Activity
Potent and selective inhibitor of noradrenalin uptake (K i values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α -adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active, clinically used antidepressant.
Check Digit Verification of cas no
The CAS Registry Mumber 71620-89-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,6,2 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 71620-89:
(7*7)+(6*1)+(5*6)+(4*2)+(3*0)+(2*8)+(1*9)=118
118 % 10 = 8
So 71620-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)
71620-89-8Relevant articles and documents
Synthesis of (S,S)-Reboxetine
Jun, Hyeyeon,Yu, Min Lee,Ko, Soo Y.
supporting information, p. 62 - 65 (2018/11/30)
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C-H to C-N Cross-Coupling of Sulfonamides with Olefins
Ma, Rulin,Christina White
supporting information, p. 3202 - 3205 (2018/03/13)
Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C(sp3)-N fragment coupling reaction between terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/SOX (sulfoxide-oxazoline) catalyzed intermolecular allylic C-H amination. A range of (56) allylic amines are furnished in good yields (avg. 75%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). Mechanistic studies reveal that the SOX ligand framework is effective at promoting functionalization by supporting cationic π-allyl Pd.
Dynamic kinetic resolution-based asymmetric transfer hydrogenation of 2-benzoylmorpholinones and its use in concise stereoselective synthesis of all four stereoisomers of the antidepressant reboxetine
Son, Se-Mi,Lee, Hyeon-Kyu
, p. 8396 - 8404 (2013/09/24)
Dynamic kinetic resolution-driven, asymmetric transfer hydrogenation reaction of 2-benzoylmorpholin-3-ones (4) proceeds efficiently to give the corresponding (2R,3S)- or (2S,3R)-2-(hydroxyphenylmethyl)morpholin-3-ones (6) with an excellent level of diastereo- and enantioselectivity and simultaneous control of two contiguous stereogenic centers in a single step. This process is employed to prepare all four stereoisomers of the antidepressant reboxetine.
