98819-73-9

Basic information

• Product Name: (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane
• Synonyms: (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane
• CAS NO: 98819-73-9
• Molecular Weight: 287.359
• Mol File: 98819-73-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane(98819-73-9)
• EPA Substance Registry System: (+)-(2S,3S)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane(98819-73-9)

Safety Data

• Hazardous Substances Data: 98819-73-9(Hazardous Substances Data)

Upstream product

• 104-54-1 3-Phenylpropenol 
• 98769-72-3 (2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 1026328-70-0 tert-Butyl-dimethyl-((4R,5R)-2-oxo-5-phenyl-2λ⁴-[1,3,2]dioxathiolan-4-ylmethoxy)-silane 
• 155930-88-4 (1R,2R)-1-<(tert-Butyldimethylsilyl)oxy>-1-phenylpropane-1,2-diol 
• 100009-29-8 (E)-1-tert-butyldimethylsilyloxy-3-phenyl-2-propene 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 93851-63-9 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 
• 1452772-76-7 (2R,3S)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide 
• 98769-71-2 (+)-(2R,3S)-3-(2-ethoxyphenoxy)-2-mesyloxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 98819-71-7 (+)-(2R,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-1-(4-nitrobenzoyloxy)-3-phenylpropane 
• 98819-70-6 (+)-(2R,3S)-3-(2-ethoxyphenoxy)-1,2-dihydro-3-phenylpropane 
• 79898-17-2 (2S,3R)-β-phenylglycidic acid 
• 98819-68-2 3-phenyl-(2R,3R)-oxiran-2-ylmethanol 

Downstream Products

• 93852-40-5 (2RS,3SR)-1-chloroacetylamino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane 
• 104968-70-9 (S,S)-reboxetine (S)-mandelate 
• 93886-32-9 (2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 71620-89-8 reboxetine 
• 71620-89-8 (S,S)-reboxetine 
• 105017-38-7 (2R,3R)-reboxetine 
• 93886-32-9 (-)-(2S,3S)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one 
• 1340546-26-0 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine (S)-(-)-camphanate 
• 635724-55-9 (2S,3S)-2-[α-(2-ethoxyphenoxy)benzyl]morpholine succinate 
• 98819-74-0 N-[(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropyl]-2-chloroacetamide 
• 1340546-27-1 (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate 
• 1340546-25-9 (2R,3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine 
• 93851-87-7 Reboxetine mesylate 
• 93853-04-4 (2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate 

Relevant articles and documents

Synthesis of (S,S)-Reboxetine

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Application of a process friendly morpholine synthesis to (S,S)-Reboxetine

We report our results on the construction of a morpholine ring system from the corresponding epoxide and amino alcohol. From this study, we were able to convert a previous four-step synthesis into a more efficient two-step process.

Process development and scale-up for (±)-reboxetine mesylate

Redevelopment of the commercial process for the synthesis of (±)-reboxetine methanesulfonate is described. An optimized and efficient process for the synthesis of (±)-reboxetine starting from cinnamyl alcohol was developed. The redeveloped process minimizes impurity formation and utilizes simplified processing to substantially improve process yield and throughput, and is suitable for the efficient synthesis of multiton quantities of reboxetine.