99018-00-5

Basic information

• Product Name: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate
• Synonyms: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate
• CAS NO: 99018-00-5
• Molecular Weight: 377.44
• Mol File: 99018-00-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate(99018-00-5)
• EPA Substance Registry System: benzyl 4-<((benzyloxy)carbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate(99018-00-5)

Safety Data

• Hazardous Substances Data: 99018-00-5(Hazardous Substances Data)

Upstream product

• 99017-93-3 ethyl 4<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate 
• 100-51-6 benzyl alcohol 
• 123-54-6 acetylacetone 

Downstream Products

• 31837-62-4 benzyl 4-<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate 

Relevant articles and documents

Pyrrole Chemistry. An Improved Synthesis of Ethyl Pyrrole-2-carboxylate Esters from Diethyl Aminomalonate

Ethyl pyrrole-2-carboxylates, versatile precursors for the total synthesis of both synthetic model and naturally occurring tetrapyrroles and porphyrins, can be prepared in greatly improved yields by the addition of 1,3-diketones and preformed diethyl aminomalonate to boiling glacial acetic acid.The method is suitable for both small- and large-scale synthesis and has proved far more reliable than the original in situ dissolving zinc reduction of diethyl oximinomalonate discovered by Kleinspehn.Yields range from 60-70percent for the dominant product isomer from unsymmetrical diketones to 75-90percent for the single product derived from symmetrical diketones.Seventeen examples of alkyl-substituted ethyl pyrrole-2-carboxylates are provided.Improved procedures are given for the preparation of the required precursors.