99387-23-2

Basic information

• Product Name: 5-nitro-2-propoxy-pyridine
• Synonyms: 5-nitro-2-propoxy-pyridine
• CAS NO: 99387-23-2
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182
• Mol File: 99387-23-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.202±0.06 g/cm3(Predicted)
• PKA: 0.08±0.22(Predicted)
• CAS DataBase Reference: 5-nitro-2-propoxy-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-2-propoxy-pyridine(99387-23-2)
• EPA Substance Registry System: 5-nitro-2-propoxy-pyridine(99387-23-2)

Safety Data

• Hazardous Substances Data: 99387-23-2(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 6819-41-6 sodium n-propoxide 
• 71-23-8 propan-1-ol 
• 28080-54-8 2-iodo-5-nitropyridine 

Downstream Products

• 52025-35-1 6-propoxypyridin-3-amine 
• 85259-48-9 2-propoxy-5-pyridinecarbaldehyde 
• 118420-43-2 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-propoxy-pyridin-3-yl)-acrylamide 
• 99387-18-5 (4-Hexyloxy-phenyl)-(6-propoxy-pyridin-3-yl)-diazene 
• 99387-17-4 (4-Ethoxy-phenyl)-(6-propoxy-pyridin-3-yl)-diazene 

Relevant articles and documents

ALKYNE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

Provided are compounds of formula (Ia) and pharmaceutically acceptable salts thereof, wherein A, B, R 1, R 2, m and n are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.