99614-60-5

Basic information

• Product Name: Ondansetron
• Synonyms: 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, (3R)- (9CI);4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-, (R)-
• CAS NO: 99614-60-5
• Molecular Formula: C₁₈H₁₉N₃O
• Molecular Weight: 293.36
• Mol File: 99614-60-5.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ondansetron(CAS DataBase Reference)
• NIST Chemistry Reference: Ondansetron(99614-60-5)
• EPA Substance Registry System: Ondansetron(99614-60-5)

Safety Data

• Hazardous Substances Data: 99614-60-5(Hazardous Substances Data)

Upstream product

• 693-98-1 2-methylimidazole 
• 27387-31-1 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 1630-73-5 N-ethyloxazolidine 
• 20073-50-1 2-(oxazolidin-3-yl)ethanol 
• 51200-87-4 4,4-dimethyl-oxazolidine 
• 108-74-7 1,3,5-trimethyl-1,3,5-triazacyclohexane 
• 51-80-9 bis-(dimethylamino)methane 
• 880-09-1 di(N-piperidinyl)methane 
• 132659-89-3 3-[(dimethylamine)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one hydrochloride 
• 99614-64-9 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 294863-10-8 ethyl 3-(1-methyl-1H-indol-2-yl)propanoate 
• 88221-09-4 ethyl 3-(1-methyl-1H-indol-2-yl)acrylate 
• 27421-51-8 1-methyl-1H-indole-2-carboxaldehyde 
• 603-76-9 1-methylindole 

Downstream Products

• 99614-64-9 9-methyl-3-methylene-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 153139-56-1 3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one 

Relevant articles and documents

C(sp2)-H Bond Multiple Functionalization in Air for Construction of Tetrahydrocarbazoles with Continuous Quaternary Carbons and Polycyclic Diversification

The C(sp2)-H function of indole ketone with diazo compound via a rhodium(II)-catalyzed intramolecular electrophilic trapping reaction under mild conditions in air was demonstrated. The established methodology provided a highly efficient approach for direct synthesis of mutisubstituted tetrahydrocarbazoles with continuous quaternary carbons. The resulting products facilitate further modification to conveniently construct tetrahydrocarbazoles with additional fused heterocyclic rings. By phenotypic screening, several products exhibit good anticancer bioctivities in osteosarcoma cell lines.

Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one and ondansetron therefrom

The present invention provides a rapid, high-yielding process for preparing 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one without using a secondary amine as a catalyst, and without using glacial acetic acid as a solvent. The present invention further provides a rapid, high-yielding process for preparing ondansetron from 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one without using alumina as a catalyst.

PROCESS FOR PREPARING 1,2,3,9-TETRAHYDRO-9-METHYL-3-[(2-METHYL-1H-IMIDAZOLE-1-YL)METHYL]-4H-CARBAZOL-4-ONE OR ITS SALT

The present invention provides an improved process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one or its salt, which is useful as an anti-vomiting agent, in a high yield under a mild condition, so as to be favorably applied to a large-scale mass production thereof.