99865-03-9

Basic information

• Product Name: 3-ethoxy-1-phenyl-prop-2-yn-1-ol
• Synonyms: 3-ethoxy-1-phenyl-prop-2-yn-1-ol
• CAS NO: 99865-03-9
• Molecular Weight: 176.215
• Mol File: 99865-03-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-ethoxy-1-phenyl-prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxy-1-phenyl-prop-2-yn-1-ol(99865-03-9)
• EPA Substance Registry System: 3-ethoxy-1-phenyl-prop-2-yn-1-ol(99865-03-9)

Safety Data

• Hazardous Substances Data: 99865-03-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 927-80-0 1-ethoxyacetylene 
• 31612-88-1 ethoxyethynyl lithium 
• 621-62-5 chloroacetaldehyde diethyl acetal 

Downstream Products

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 4610-69-9 (Z)-ethyl cinnamate 
• 4192-77-2 ethyl cinnamate 
• 19713-73-6 methyl (2Z)-3-phenylprop-2-enoate 
• 103-26-4 Methyl cinnamate 
• 201221-74-1 (Z)-2-iodo-3-phenylacrylic acid ethyl ester 
• 172656-35-8 2-benzylidene-pent-4-enoic acid ethyl ester 
• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 
• 110556-15-5 3-Hydroxy-2-oxo-3-phenylpropionic acid ethyl ester 
• 4198-15-6 3-hydroxy-N,3-diphenylpropanamide 

Relevant articles and documents

A Single-Flask Synthesis of Morita-Baylis-Hillman Adducts from Ethoxyacetylene and Carbonyl Compounds: Synthesis of Subamolides D and e

Sequential treatment of (ethoxyethynyl)lithium with aldehydes and/or ketones (2 and 4) and BF3·OEt2 gives rise to β-hydroxyenoates 5 in good to excellent overall yields. Similarly, the combination of 1 (M = Li) and dicarbonyl compounds 6 (X = O) or keto/aldehyde acetals (X = OMe) followed by the addition of a Lewis acid leads to five-, six-, and seven-membered hydroxycycloalkene carboxyates. The utility of this method is demonstrated in the synthesis of the α-alkylidene lactone natural products subamolide D and E.

A Convenient Procedure for the Preparation of Ethoxyacetylene and Ethoxyethynyl Carbinols

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