99873-50-4Relevant articles and documents
Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents
Miao, Yuhang,Sun, Jie,Wang, Xiaojing,Yang, Jie,Yun, Yinling
, (2020/01/03)
Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted 4-arylcoumarin derivatives were synthesised, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity, MAO inhibitory activity, and antioxidant activity. Most of the compounds were found to exhibit high inhibitory activity, and individual compounds have extremely excellent activities. Therefore 4-arylcoumarins provides an idea for drugs design for the development of therapeutic or preventive agents for AD.
An efficient bromination of alkenes using cerium(IV) ammonium nitrate (CAN) and potassium bromide
Nair, Vijay,Panicker, Sreeletha B,Augustine, Anu,George, Tesmol G,Thomas, Siji,Vairamani
, p. 7417 - 7422 (2007/10/03)
Bromination of alkenes using a combination of potassium bromide and cerium(iv) ammonium nitrate (CAN) in a two phase system consisting of water and dichloromethane affords the corresponding dibromides in excellent yield. The reaction most likely involves the addition of the bromine radical generated from bromide ion by CAN and subsequent formation of the dibromide.
Enolethers and their use as a fungicide
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, (2008/06/13)
Enolethers and thioenolethers of formula I STR1 are disclosed. The compounds are useful for combatting phytopathogenic fungi.