99973-40-7

Basic information

• Product Name: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole
• Synonyms: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole
• CAS NO: 99973-40-7
• Molecular Weight: 247.345
• Mol File: 99973-40-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole(99973-40-7)
• EPA Substance Registry System: 4-(4-methylphenyl)-5-thiocyanato-2-aminothiazole(99973-40-7)

Safety Data

• Hazardous Substances Data: 99973-40-7(Hazardous Substances Data)

Upstream product

• 2103-91-5 2-amino-4-(p-methylphenyl)-1,3-thiazole 
• 1147550-11-5 ammonium thiocyanate 
• 333-20-0 potassium thioacyanate 
• 89108-49-6 1-(1-azidovinyl)-4-methyl benzene 
• 163276-49-1 1-thiocyanatopyrrolidine-2,5-dione 

Relevant articles and documents

Metal-Free One-Pot Chemoselective Thiocyanation of Imidazothiazoles and 2-Aminothiazoles with in situ Generated N-Thiocyanatosuccinimide

A chemoselective thiocyanation of imidazothiazoles and 2-aminothiazoles with use of in situ generated N-thiocyanatosuccinimide (NTS) at room temperature is described. The protocol offers mild reaction conditions and high chemoselectivity for electrophilic substitution in imidazothiazoles over nucleophilic substitution. This method provides metal-free and easy conversion of imidazothiazoles and 2-aminothiazoles into their corresponding C-3 and C-5 thiocyanates, respectively, in good to excellent yield. The present protocol also offers the effective thiocyanation of bifunctional imidazothiazoles containing aliphatic -OH and C(sp 2)-H bond functionalities.

Visible light thiocyanation of: N -bearing aromatic and heteroaromatic compounds using Ag/TiO2 nanotube photocatalyst

In this study, Ag/TiO2 nanotubes (Ag/TNT) were synthesized via simple hydrothermal process, and this photocatalyst was successfully exploited in thiocyanation reactions at room temperature under visible light irradiation. Four classes of important heterocyclic compounds including indole, aniline, pyrrole and 2-amino thiazole derivatives via Ag/TNT treated with ammonium thiocyanate formed the corresponding thiocyano compounds in moderate to excellent yields. Plasmonic property and catalytic performance of Ag nanoparticles (which mainly deposited on the surface of TNT) in absorbing species containing sulfur atoms were key components for the reactions to proceed. This potent, simple and versatile protocol reported for the first time afforded thiocyanation reactions of aniline, pyrrole and 2-amino thiazole derivatives under visible light. The reactions proceeded through a radical pathway by applying air molecular oxygen as a low-cost and environmentally friendly terminal oxidant.

Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts

A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, respectively, catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.