Scheme of the synthesis of chalcones (3a – h)

March 04, 2024

• Title:       

  Scheme of the synthesis of chalcones (3a – h)

• Image Source:

  Microwave induced improved synthesis of some novel substituted 1, 3-diarylpropenones and their antimicrobial activity

• Mark:

  Figure 1

• Associated context:

  To a solution of 4-hydroxy-3,5-dinitroacetophenone (0.01 mol) and substituted aromatic  aldehyde (0.01 mol) in ethanol (5 mL) taken in 100 mL borosil flask, was added  montmorrilonite K 10 clay (4g). The mixture was uniformly mixed with glass rod and air  dried to remove the solvent. Adsorbed material was irradiated inside a microwave oven for  4-6 min. at medium power level (600 W). After the completion of the reaction (monitored  by TLC), the reaction mixture was cooled at room temperature and the product was  extracted with ethanol (2x20 mL). Removal of the solvent and subsequent recrystallisation  with ethanol resulted analytical samples of 3a-h. The scheme of the synthesis of title compounds is shown in Figure 1 and the Comparison of reaction times and yields of compound (3a-h) under microwave and classical methods is showing in Table 1.