Structures of distamycin A and furamidine B

March 20, 2024

• Title:       

  Structures of distamycin A (CAS 636-47-5) and furamidine B

• Image Source:

  Synthesis and biological evaluation of distamycin analogues - New potential anticancer agents

• Mark:

  Figure 1

• Associated context:

  This paper is in continuation of rational drug design program aiming to develop distamycin analogues, potential minor-groove binders, and inhibitors of topoisomer-ases. We developed new  compounds with skeletons that combine the structural features of distamycin A and furamidine B (Fig. 1). The purpose of this work was the synthesis of eight new compounds containing benzene connected with heteroaromatic rings, in different configurations. Preliminary evaluation of their biological properties – antiproli-ferative and cytotoxic activity in MCF-7 and MDA-MB-231 cell lines and the capacity to inhibit human topoisomerases I and II in vitro were planned. We also investigated the binding of compounds 1–8 to plasmid DNA employing the ethidium-bromide assay.