Spectrofluorimetric determination of Doxepin hydrochloride (cas 1229-29-4) in commercial dosage forms via ion pair complexation with alizarin red S
-
Add time:07/25/2019 Source:sciencedirect.com
A simple and sensitive spectrofluorimetric method has been developed for the determination of Doxepin hydrochloride (cas 1229-29-4) in pharmaceutical preparations. It is based on the formation of ion-pair complex between doxepin and alizarin red S at pH 3.09. The ion pair complex was extracted in dichloromethane and the fluorescence intensity was measured at 560 nm after excitation at 490 nm. The optimum conditions for determination were also investigated. The linear range and detection limit were found to be 2–14 and 0.55 μg/ml, respectively. The method has been successfully applied for the analysis of drug in commercial dosage forms. No interference was observed from common pharmaceutical adjuvant. Statistical comparison of the results obtained by the proposed method with that of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.
We also recommend Trading Suppliers and Manufacturers of Doxepin hydrochloride (cas 1229-29-4). Pls Click Website Link as below: cas 1229-29-4 suppliers
Prev:New estrogen receptor antagonists. 3,20-Dihydroxy-19-norpregna-1,3,5(10)-trienes: Synthesis, molecular modeling, and biological evaluation
Next:Study of the interaction between Doxepin hydrochloride (cas 1229-29-4) and bovine serum albumin by spectroscopic techniques) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Transbuccal delivery of doxepin: Studies on permeation and histological investigation08/01/2019
- Therapeutic rationale for low dose doxepin in insomnia patients07/31/2019
- High-performance Liquid Chromatographic Determination of (Z)- and (E)-Doxepin hydrochloride (cas 1229-29-4) Isomers07/30/2019
- Extractive spectrophotometric methods for the determination of Doxepin hydrochloride (cas 1229-29-4) in pharmaceutical preparations using titanium (IV) and iron (III) thiocyanate complexes07/29/2019
- Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study07/28/2019
- Spectroscopic study of charge transfer complexation between doxepin and π–acceptors and its application in quantitative analysis07/27/2019
- Study of the interaction between Doxepin hydrochloride (cas 1229-29-4) and bovine serum albumin by spectroscopic techniques07/26/2019
-
Health and Chemical more >