Short CommunicationPharmacokinetics of HYDROCODONE (cas 125-29-1) and hydromorphone after oral HYDROCODONE (cas 125-29-1) in healthy Greyhound dogs

Add time:09/09/2019    Source:sciencedirect.com

The purpose of this study was to determine the pharmacokinetics of HYDROCODONE (cas 125-29-1) and its active metabolite hydromorphone in six healthy Greyhound dogs. Hydrocodone bitartrate was administered at a targeted dose of 0.5 mg/kg PO. Plasma concentrations of hydrocodone and hydromorphone were determined by liquid chromatography triple quadrupole mass spectrometry. The mean hydrocodone CMAX was 11.73 ng/mL at 0.74 h with a terminal half-life of 1.60 h. The mean hydromorphone CMAX was 5.2 ng/mL at 1.37 h with a terminal half-life of 3.07 h. Mean plasma hydromorphone concentrations exceeded 2 ng/mL from 0.5 to 8 h after hydrocodone administration. Further studies assessing the antinociceptive effects of oral hydrocodone are needed.

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