Some observations on SOLASODINE (cas 126-17-0) reactivity
-
Add time:09/24/2019 Source:sciencedirect.com
This article presents new transformations of SOLASODINE (cas 126-17-0) – a representative steroid alkaloid sapogenin from the Solanum family. Oxidation of N,O-diacetylated solasodine with either NaNO2/BF3·Et2O or t-BuONO/BF3·Et2O resulted in partial degradation of the side chain to (20S)-3β-acetoxypregn-5-ene-20,16β-carbolactone (vespertilin acetate). The same starting compound when treated with TMSOTf afforded the corresponding pseudosapogenin after aqueous work-up. However, when the crude reaction mixture was directly subjected to purification on a silica gel column, efficient autoxidation to pregna-5,16-dien-3β-ol-20-one acetate was observed. One-step synthesis of this important drug intermediate from spirosolan alkaloids may be potentially exploited for large-scale production of steroid hormones.
We also recommend Trading Suppliers and Manufacturers of SOLASODINE (cas 126-17-0). Pls Click Website Link as below: cas 126-17-0 suppliers
Prev:SOLASODINE (cas 126-17-0)-3-O-β-d-glucopyranoside is hydrolyzed by a membrane glucosidase into active molecule SOLASODINE (cas 126-17-0) against Candida albicans
Next:SOLASODINE (cas 126-17-0) inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Facile synthesis of SOLASODINE (cas 126-17-0) based on a mild halogenation-ring opening reaction of spiroketals in steroidal sapogenins09/30/2019
- Methyl jasmonate elicits the SOLASODINE (cas 126-17-0) production and anti-oxidant activity in hairy root cultures of Solanum trilobatum L.09/29/2019
- Regeneration, Repair, and Developmental NeuroscienceResearch PaperThe naturally occurring steroid SOLASODINE (cas 126-17-0) induces neurogenesis in vitro and in vivo09/28/2019
- Development and validation a liquid chromatography mass spectrometry for determination of SOLASODINE (cas 126-17-0) in rat plasma and its application to a pharmacokinetic study10/01/2019
- Neuropharmacology and analgesiaSOLASODINE (cas 126-17-0) protects rat brain against ischemia/reperfusion injury through its antioxidant activity09/27/2019
- A facile and efficient method for the synthesis of SOLASODINE (cas 126-17-0) from diosgenin09/26/2019
- SOLASODINE (cas 126-17-0) inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression09/25/2019
- SOLASODINE (cas 126-17-0)-3-O-β-d-glucopyranoside is hydrolyzed by a membrane glucosidase into active molecule SOLASODINE (cas 126-17-0) against Candida albicans09/10/2019
- SOLASODINE (cas 126-17-0) reverses stemness and epithelial-mesenchymal transition in human colorectal cancer09/09/2019