A facile and efficient method for the synthesis of SOLASODINE (cas 126-17-0) from diosgenin
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Add time:09/26/2019 Source:sciencedirect.com
A facile and high-yielding route for the synthesis of SOLASODINE (cas 126-17-0) from diosgenin is devised. Ring opening of steroidal spiroketal under mild conditions with trifluoroacetyl trifluoromethanesulfonate (TFAT) provides an applicable protocol to prepare key intermediates 4 or 3-Ac-solasodine, which can potentially serve as a platform for the selective functionalization of C(3)–OH and N–H of solasodine. The simple operations without purification by column chromatography make this method suitable to scale up.
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