Combination of 7-Hydroxycoumarin (cas 93-35-6) in a platinum(IV) complex derived from cisplatin enhanced cytotoxicity with multiple mechanisms of action
-
Add time:07/18/2019 Source:sciencedirect.com
A novel compound, Cou-platin, composed of 7-Hydroxycoumarin (cas 93-35-6) and a platinum(IV) moiety derived from cisplatin was designed and synthesized. Significantly, Cou-platin exhibited more potent in vitro antitumor activity against all tested cancer cell lines than that of cisplatin, which was mainly attributed to the liberation of cisplatin and 7-hydroxycoumarin upon reduction with a biomolecular agent. Besides, cellular accumulation of Cou-platin was dramatically increased among several cancer cells in contrast to cisplatin. Flow cytometry study revealed that Cou-platin arrested cell cycle at G2 phase and induced cell apoptosis. Western blots results indicated that it not only activated cell apoptosis pathway, but also inhibited extracellular regulated protein kinases/mitogen-activated protein kinase pathway. In vivo tests showed that Cou-platin, at equimolar dose to cisplatin, could inhibit tumor growth in nude mouse HCT116 tumor xenograft models almost as cisplatin and oxaliplatin, but with less toxicity.
We also recommend Trading Suppliers and Manufacturers of 7-Hydroxycoumarin (cas 93-35-6). Pls Click Website Link as below: cas 93-35-6 suppliers
Prev:Structural investigation of Cu(II) complexes with dibromo 7-Hydroxycoumarin (cas 93-35-6) derivatives using methodology based on XAS
Next:Hepatoprotective effect of 7-Hydroxycoumarin (cas 93-35-6) against Methyl glyoxal toxicity via activation of Nrf2) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- XAFS study of bioactive Cu(II) complexes of 7-Hydroxycoumarin (cas 93-35-6) derivatives in organic solvents07/24/2019
- Activation of β1-adrenoceptor triggers oxidative stress mediated myocardial membrane destabilization in isoproterenol induced myocardial infarcted rats: 7-Hydroxycoumarin (cas 93-35-6) and its counter action07/23/2019
- Calorimetric and computational study of 7-Hydroxycoumarin (cas 93-35-6)07/22/2019
- Incorporation of photoluminescent 7-Hydroxycoumarin (cas 93-35-6) units onto a polyethylene matrix by means of gamma radiation07/20/2019
- 7-Hydroxycoumarin (cas 93-35-6) modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils07/21/2019
- Hepatoprotective effect of 7-Hydroxycoumarin (cas 93-35-6) against Methyl glyoxal toxicity via activation of Nrf207/19/2019
- Structural investigation of Cu(II) complexes with dibromo 7-Hydroxycoumarin (cas 93-35-6) derivatives using methodology based on XAS07/17/2019
- Synthesis and evaluation of bi-functional 7-Hydroxycoumarin (cas 93-35-6) platinum(IV) complexes as antitumor agents07/16/2019
- Inhibition of human cytochrome P450 2A6 by 7-Hydroxycoumarin (cas 93-35-6) analogues: Analysis of the structure-activity relationship and isoform selectivity07/15/2019
-
Health and Chemical more >
-
Related Products