Activation of β1-adrenoceptor triggers oxidative stress mediated myocardial membrane destabilization in isoproterenol induced myocardial infarcted rats: 7-Hydroxycoumarin (cas 93-35-6) and its counter action
-
Add time:07/23/2019 Source:sciencedirect.com
Activation of β1-adrenoceptor stimulates myocardial membrane destabilization in isoproterenol induced rats. Male albino Wistar rats were pre and co-treated with 7-Hydroxycoumarin (cas 93-35-6) (16 mg/kg body weight) daily for 8 days. Myocardial infarction was induced into rats by the subcutaneous administration of isoproterenol (100 mg/kg body weight) at an interval of 24 h daily for a period of two days (7th and 8th day). The levels/activities of serum cardiac troponin-T, lactate dehydrogenase and the concentrations of heart lipid peroxidation products were significantly increased and the antioxidant status was significantly decreased in isoproterenol induced rats. Furthermore, the activity of sodium/potassium-dependent adenosine triphosphatase was significantly decreased and the activities of calcium and magnesium-dependent adenosine triphosphatases were significantly increased in the heart of isoproterenol induced myocardial infarcted rats. Isoproterenol induced rats also revealed increased concentrations of sodium and calcium and decreased concentrations of potassium in the heart. 7-hydroxycoumarin pre- and co-treatment showed considerable impact on all biochemical parameters assessed. Also, 7-HC greatly reduced the infarct size of the myocardium. The in vitro study confirmed its potent free radical scavenging activity. Thus, the present study revealed that 7-HC attenuates myocardial membrane destabilization by reinstating the activities/levels of adenosine triphosphatases and minerals in isoproterenol induced rats by inhibiting oxidative stress. These effects are attributed to the membrane stabilizing and free radical scavenging properties of 7-hydroxycoumarin.
We also recommend Trading Suppliers and Manufacturers of 7-Hydroxycoumarin (cas 93-35-6). Pls Click Website Link as below: cas 93-35-6 suppliers
Prev:Calorimetric and computational study of 7-Hydroxycoumarin (cas 93-35-6)
Next:XAFS study of bioactive Cu(II) complexes of 7-Hydroxycoumarin (cas 93-35-6) derivatives in organic solvents) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- XAFS study of bioactive Cu(II) complexes of 7-Hydroxycoumarin (cas 93-35-6) derivatives in organic solvents07/24/2019
- Calorimetric and computational study of 7-Hydroxycoumarin (cas 93-35-6)07/22/2019
- Incorporation of photoluminescent 7-Hydroxycoumarin (cas 93-35-6) units onto a polyethylene matrix by means of gamma radiation07/20/2019
- 7-Hydroxycoumarin (cas 93-35-6) modulates the oxidative metabolism, degranulation and microbial killing of human neutrophils07/21/2019
- Hepatoprotective effect of 7-Hydroxycoumarin (cas 93-35-6) against Methyl glyoxal toxicity via activation of Nrf207/19/2019
- Combination of 7-Hydroxycoumarin (cas 93-35-6) in a platinum(IV) complex derived from cisplatin enhanced cytotoxicity with multiple mechanisms of action07/18/2019
- Structural investigation of Cu(II) complexes with dibromo 7-Hydroxycoumarin (cas 93-35-6) derivatives using methodology based on XAS07/17/2019
- Synthesis and evaluation of bi-functional 7-Hydroxycoumarin (cas 93-35-6) platinum(IV) complexes as antitumor agents07/16/2019
- Inhibition of human cytochrome P450 2A6 by 7-Hydroxycoumarin (cas 93-35-6) analogues: Analysis of the structure-activity relationship and isoform selectivity07/15/2019
-
Health and Chemical more >
-
Related Products