17647-40-4

Basic information

• Product Name: (+/-)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate
• Synonyms: (+/-)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate
• CAS NO: 17647-40-4
• Molecular Weight: 219.24
• Mol File: 17647-40-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (+/-)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate(17647-40-4)
• EPA Substance Registry System: (+/-)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate(17647-40-4)

Safety Data

• Hazardous Substances Data: 17647-40-4(Hazardous Substances Data)

Upstream product

• 873-67-6 benzonitrile oxide 
• 80-62-6 methacrylic acid methyl ester 
• 21692-86-4 5-methyl-3-phenyl-5-trimethylsilanylethynyl-4,5-dihydro-isoxazole 
• 698-16-8 benzohydroximoyl chloride 
• 622-42-4 1-nitro-1-phenylmethane 
• 108199-02-6 O-ethoxycarbonylbenzohydroximoyl chloride 
• 932-90-1 Benzaldoxime 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 932-90-1 syn-benzaldehyde oxime 
• 611-73-4 Benzoylformic acid 
• 25327-36-0 (Z)-2-(hydroxyimino)-2-phenylacetic acid 
• 100-52-7 benzaldehyde 
• 934-16-7 phenylhydroxamoyl chloride 

Downstream Products

• 17647-40-4 (S)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate 
• 157238-86-3 (R)-methyl 3-phenyl-5-methyl-4,5-dihydroisoxazole-5-carboxylate 
• 1424395-20-9 C₃₀H₃₂N₂O₆ 
• 1424395-21-0 C₂₉H₂₈Cl₂N₂O₅ 
• 842954-77-2 5-methyl-3-phenyl-Δ²-isoxazoline-5-carboxylic acid 

Relevant articles and documents

Electrochemical Synthesis of Isoxazolines: Method and Mechanism

An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled regio- and diastereoselective reaction with electron-deficient alkenes. Additionally, in-situ reaction monitoring methods compatible with electrochemistry equipment have been developed in order to probe the reaction pathway. Supporting analyses from kinetic (time-course) modelling and density functional theory support a stepwise, radical-mediated mechanism, and discounts hypothesised involvement of closed shell [3+2] cycloaddition pathways.

Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists

A novel set of compounds containing a 4,5-dihydro-5-methylisoxazoline have been successfully designed as VLA-4 receptor antagonists. Compound (14p) had a high receptor binding affinity of 4 nM and also found to be metabolically stable in vitro.

CASPASE INHIBITORS CONTAINING ISOXAZOLINE RING

The present invention relates to an isoxazoline derivative as an inhibitor against various caspases, a process for preparing the same, and a therapeutic composition for preventing inflammation and apoptosis comprising the same