33491-05-3

Basic information

• Product Name: Benzene, 1-(bromoethynyl)-4-methyl-
• Synonyms: 1-bromo-2-(4-methylphenyl)acetylene;1-bromo-2-(p-methylphenyl)acetylene;1-(4-methylphenyl)-2-bromoacetylene;1-(bromoethynyl)-4-methylbenzene;(4-methylphenyl)ethynyl bromide;1-bromoethynyl-4-methyl-benzene
• CAS NO: 33491-05-3
• Molecular Formula: C9H7Br
• Molecular Weight: 195.059
• Mol File: 33491-05-3.mol
• Article Data: 76

Chemical Properties

• Boiling Point: 97 - 98 °C (14 mmHg)
• CAS DataBase Reference: Benzene, 1-(bromoethynyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(bromoethynyl)-4-methyl-(33491-05-3)
• EPA Substance Registry System: Benzene, 1-(bromoethynyl)-4-methyl-(33491-05-3)

Safety Data

• Hazardous Substances Data: 33491-05-3(Hazardous Substances Data)

Upstream product

• 60512-56-3 1-(2,2-dibromovinyl)-4-methylbenzene 
• 90-02-8 salicylaldehyde 
• 558-13-4 carbon tetrabromide 
• 104-87-0 4-methyl-benzaldehyde 
• 1777-53-3 1-(p-tolyl)-2-(triphenylphosphoranylidene)ethanone 
• 104-81-4 4-Methylbenzyl bromide 
• 506-68-3 bromocyane 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 75-25-2 Bromoform 
• 3201-61-4 -triphenyl-phosphoran 
• 72591-22-1 p-(2,2,2-Tribromaethyl)-toluol 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 23464-20-2 5,5-Diethoxy-1-p-methylphenylpenta-1,3-diin 
• 35205-60-8 diethyl 2-(1-(p-tolyl)ethylidene)malonate 
• 1429402-63-0 N-((4-methyl)phenylethynyl)-S-methyl-S-phenylsulfoximine 
• 1385634-93-4 1-((Z)-4-p-tolylbut-1-en-3-ynyl)benzene 
• 1620636-43-2 1-((E)-hept-3-en-1-ynyl)-4-methylbenzene 
• 1620057-22-8 bis(2-methoxyphenyl)(phenyl)(p-tolylethynyl)phosphonium bromide 
• 1638667-32-9 (Z)-5-(2-bromo-3-chloro-3-(p-tolyl)allyl)dihydrofuran-2(3H)-one 
• 1629605-91-9 C₂₉H₂₅NO₂S 
• 1629605-90-8 C₂₈H₂₂ClNO₂S 
• 1629605-84-0 C₂₉H₂₅NO₂S 
• 1629605-78-2 C₂₈H₂₂FNO₂S 
• 1629605-72-6 C₂₈H₂₃NO₂S 
• 1599458-33-9 2-methyl-2-(p-tolylethynyl)tetrahydrofuran 
• 3287-02-3 4-(phenylethynyl)toluene 

Relevant articles and documents

Regio- and Stereoselective N-addition to an Open Bromo Vinyl Cation

A protocol for the synthesis of thus far inaccessible bromo vinyl triflimides is presented. Our previously reported concept of assisted vinyl cation formation was engaged to achieve both a protonation of relatively electron poor bromo alkynes and a reaction with high regio- and stereoselectivity. To the best of our knowledge, this is the first stereoselective addition of an N-nucleophile to an open β-halovinyl cation.

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.

Catalytic Synthesis of Dibenzazepines and Dibenzazocines by 7-Exo- and 8-Endo-Dig-Selective Cycloisomerization

The 7-exo- and 8-endo-dig-selective gold-catalyzed cycloisomerizations of 2-propargylamino biphenyl derivatives were developed. The reaction of terminal alkynes gave dibenzo[b,d]azepines by 7-exo-dig cycloisomerization. In contrast, when internal alkynes were subjected to the reaction, 8-endo-dig cycloisomerization proceeded to provide dibenzo[b,d]azocines. The nucleophilicity at the reaction site and the electron-withdrawing effect of a tosyl group were important for the present selective transformation. This protocol could be used for ynamide substrates and a silver-catalyzed reaction gave 7-exo-dig products selectively.