6798-33-0 Usage
Description
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate, also known as benzbromarone, is a carbamate derivative that serves as an antirheumatic and uricosuric agent. It functions by inhibiting the reabsorption of uric acid in the kidneys, which results in increased excretion of uric acid in urine. Benzbromarone has been studied for its potential anti-inflammatory and antioxidant properties, but its use is limited in some countries due to rare but severe liver toxicity.
Uses
Used in Pharmaceutical Industry:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as an antirheumatic agent for the treatment of gout and hyperuricemia. It is effective in reducing the levels of uric acid in the body, providing relief from the symptoms associated with these conditions.
Used in Gout Management:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a uricosuric agent to increase the excretion of uric acid in the urine, helping to prevent the formation of uric acid crystals and reduce the risk of gout attacks.
Used in Research:
Benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a subject of study for its potential anti-inflammatory and antioxidant properties, which could lead to the development of new treatments for various inflammatory and oxidative stress-related conditions.
Used in Drug Safety Monitoring:
Due to its association with rare but severe liver toxicity, benzyl (2,2,2-trifluoro-1-hydroxyethyl)carbamate is used as a case study for monitoring drug safety and understanding the potential adverse effects of medications, ensuring that their benefits outweigh the risks for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 6798-33-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,9 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6798-33:
(6*6)+(5*7)+(4*9)+(3*8)+(2*3)+(1*3)=140
140 % 10 = 0
So 6798-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H10F3NO3/c11-10(12,13)8(15)14-9(16)17-6-7-4-2-1-3-5-7/h1-5,8,15H,6H2,(H,14,16)
6798-33-0Relevant articles and documents
Preparation method of chiral trifluoromethyl amine derivatives
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Paragraph 0058; 0063; 0064; 0065, (2019/01/04)
The invention discloses a preparation method of chiral trifluoromethyl amine derivatives. The structural formula of the chiral trifluoromethyl amine derivatives is shown in a formula I; the preparation method comprises the following steps: mixing carbonyl compounds and N, O-acetal with a chiral tertiary diamine organic small molecule catalyst and acid and then carrying out a reaction so as to obtain the chiral trifluoromethyl amine compounds. The chiral trifluoromethyl amine compounds are prepared by using the chiral tertiary diamine organic small molecule catalyst with a simple structure forcatalyzing without needing a solvent, and are synthesized in one step, so that the preparation method is simple and efficient. (The formula I is described in the description.).
Synthesis of α-trifluoromethyl-α-hydroxycarboxylate dervatives and their phosphorus-containing analogs with the use of fluorinated diazo compounds
Titanyuk,Vorob'eva,Osipov,Beletskaya
experimental part, p. 619 - 623 (2010/10/04)
Approach was developed underlain by the use of fluorinated diazocompounds to the synthesis of derivatives of α-trifluoromethyl-α- hydroxycarboxylic acids and their phosphorus-containing analogs, α-trifluoromethyl-α-hydroxyphosphonic acids. Methyl 2-diazo-3,3,3-trifluoropropionate and diethyl 1-diazo-2,2,2- trifluoroethylphosphonate under the action of catalytic quantities of dirhodium tetraacetate Rh2(OAc)4 easily inserted into the O-H bond leading to the formation of the corresponding products in high yields. Pleiades Publishing, Ltd., 2010.
Expedient synthesis of perhaloaldehyde N-acyl hemiaminals
Ingrassia, Laurent,Mulliez, Michel
, p. 1731 - 1738 (2007/10/03)
Various perhaloaldehyde N-acyl hemiaminals 1 are readily prepared in high yields by condensation of amides 7 with easily available perhaloaldehyde O-ethyl hemiacetals 8 or hydrates 9 in the presence of 5 A molecular sieves.
