Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
In a project to find novel neutral P1 fragments for the synthesis of thrombin inhibitors with improved pharmacokinetic properties, fragments containing a benzothiazole guanidine scaffold were identified as weak thrombin inhibitors. WaterLOGSY (Water-Ligan
Karle, Michael,Knecht, Wolfgang,Xue, Yafeng
supporting information; experimental part
p. 4839 - 4843
(2012/08/13)
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