- Phosphinylmethylphosphinates as chelating ligands
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(Dimethylphosphinyl)-, (methylphenylphosphinyl)-, and (diphenylphosphinyl)methylphenylphosphinic acids have been prepared by hydrolysis of the Michaelis-Arbuzov reaction products of the appropriate chloromethylphosphine oxides and diethyl phenylphosphonite. They react with Zn(C2H3O2)2·2H2O and Cr(C5H7O2)3 under suitable conditions to yield the corresponding bis and tris chelates, except for the diphenyl-chromium(III) derivative, which was prepared in low yield via the chromium(II) derivative. The zinc derivatives are dimers, the chromium derivatives monomers. The metal chelates are more thermally stable than the corresponding acetylacetonates. Their infrared and 1H n.m.r. spectra are discussed.
- King,Block,Popoff
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- NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME
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Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is —(CH2)n-Z-(CH2)m—PO(OR7)(OR8), —(CH2)nZ-(CH2)m—PO(OR7)Rg, —(CH2)n-Z-(CH2)m—OPO(OR7)Rg, —(CH2)nZ—(CH2)m—OPO(R9)(R10), or —(CH2)nZ—(CH2)m—PO(R9)(R10);R5 and R6 are independently selected from H, alkyl and halogen;Y is R7(CH2)s or is absent; andX, n, Z, m, R4, R5, R6, R7, and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
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Page/Page column 102-103
(2008/06/13)
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- The effect of the phosphoryl group on the rate and mechanism of SN-substitution at the saturated carbon atoms
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The reactivity of diarylphosphine oxides RR'P(O)CH2X with p-O2NC6H4ONa in DMF have been studied.The reaction rate increases with the electrodrawing properties of the substituents on R and R' in the following way: p-Me2NC6H4 2 reaction rate of diphenylphosphine oxides has been investigated.The reactivity increases as follows Cl I Br OTs.A reaction mechanism is suggested.
- Tsvetkov, E. N.,Tkachenko, S. E.,Yarkevich, A. N.
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p. 339 - 341
(2007/10/02)
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- Functional Derivatives of Trimethylphosphane, XV. (Chloromethyl)dimethylphosphane
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(Chloromethyl)dimethylphosphane, Me2P(CH2Cl) (3), which is unstable at room temperature, has been synthesized.Reactions with O2, CH3Br and LiPMe2 give Me2P(O)(CH2Cl) (4), Br (5b) and Me2PCH2PMe2 (2), respectively.NMR data for these and related compounds are given.
- Karsch, Hans Heinz
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p. 823 - 827
(2007/10/02)
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- Production of halogen-containing tertiary phosphine oxides
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Production of halogen-containing tertiary phosphine oxides of the general formula (I) STR1 in which R1 stands for an alkyl, halogenoalkyl, alkenyl, halogenoalkenyl, alkinyl or halogenoalkinyl radical, each of these radicals containing from 1 to 18 carbon atoms, or stands for a cycloalkyl, a halogenated cycloalkyl, an aryl, a halogenated aryl, an aralkyl or a halogenated aralkyl radical, and X stands for halogen. The oxides are made by subjecting a compound of the general formula (II) STR2 in which R has the same meaning as R1 and X stands for halogen, to thermal treatment in the presence of hydrogen halide at atmospheric or at elevated pressure so as to split off water and formaldehyde in vapor form therefrom; by continuously freeing the resulting reaction mixture from the said components in vapor form; by terminating the reaction and thereafter stripping off the hydrogen halide from the reaction mixture by introducing an inert gas thereinto; and by purifying the remaining crude product by distillation or recrystallization.
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