- AN INDUSTRIAL SCALE PROCESS FOR THE PREPARATION OF PROTHIOCONAZOLE
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The present invention relates to an industrial scale process for the preparation of Prothioconazole (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and greater chemical purity.
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- Synthesis method and application of prothioconazole
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The invention relates to the technical field of chemical drug synthesis, and especially relates to a synthesis method and application of prothioconazole. The synthesis method of prothioconazole comprises the following steps: 1, carrying out an epoxidation reaction on a compound represented by formula IV to obtain a compound represented by formula III; 2, performing nucleophilic addition reaction on the compound of the formula III and triazole to obtain a compound represented by formula II; and 3, carrying out a vulcanization reaction on the compound of the formula II to obtain prothioconazolerepresented by formula I. The prothioconazole is prepared by taking the compound of the formula IV as an initial raw material through the epoxidation reaction, the nucleophilic addition reaction and the vulcanization reaction, so the cost is low, safety and high efficiency are achieved, potential safety hazards are avoided, the overall yield is high, reaction conditions are mild, the raw materialutilization rate is increased, three wastes can be obviously reduced, and the method has certain significance for industrial production.
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- IMPROVED PROCESS FOR PREPARATION OF INTERMEDIATES
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PCT00760 20 ABSTRACT Disclosed herein is a process for preparation of 1-chloro-2-(1- chlorocyclopropyl)-3-(2-chlorophenyl)propan-2-ol (compound of formula (I)) 5 and 2-(1-chlorocyclopropyl)-2-[(2-chlorophenyl)methyl]oxirane (compound of formula (II)).
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Page/Page column 10; 15-17
(2019/10/01)
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- METHOD OF SYNTHESIZING 1,2,4-TRIAZOLE-3-THIONE COMPOUNDS AND INTERMEDIATES THEREOF
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Disclosed is a method of synthesizing 1,2,4-triazole-3-thione compounds and intermediates thereof. The method includes reacting a hydrazine with glyoxylic acid to form a hydrazono acetic acid intermediate followed by reacting the latter with thiocyanate to obtain the 1,2,4-triazole-3-thione compound. The raw materials involved in the present method are readily available, and the reaction is very specific in terms of regioselectivity, resulting in minimum by-product and high product yield. There are neither specific requirements for special equipment nor special operations such as high vacuum, high temperature, anhydrous and oxygen-free manipulations. The process is simple and generates minimum wastes, suitable for industrial production.
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- Method for continuously producing prothioconazole by using microchannel reactor and microchannel system (by machine translation)
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In the microchannel reactor, 2 - (1 - chlorocyclopropyl) -1 - (2 - chlorophenyl) -3 - hydrazine-propan -2 - alcohol is used as a raw material to continuously complete the preparation process of propiconazole through a cyclization and oxidation two-step re
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Paragraph 0038; 0042-0044; 0045; 0049-0051; 0052; 0056-0058
(2019/10/01)
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- A PROCESS FOR PREPARATION OF FUNGICIDALLY ACTIVE TRIAZOLE COMPOUNDS
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The present invention relates to a process for the preparation of fungicidally active triazole compounds wherein said process uses homologous cage amines as the catalyst.
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Page/Page column 36; 37
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- Preparation method of prothioconazole
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The invention relates to a preparation method of prothioconazole. The preparation method comprises that a compound IV undergoes a reaction at 20 to 120 DEG C in the presence of an oxidizing agent and a solvent, and after the reaction, the product is treated to form prothioconazole. The preparation method has mild reaction conditions, utilizes cheap and easily available raw materials, has simple processes, is environmentally friendly and clean in regents and reaction processes, greatly reduces three wastes, is suitable for industrial production, and realizes a high yield of a final product and high content.
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- Method for synthesizing prothioconazole and optical active body thereof and intermediate
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The invention discloses a method for synthesizing prothioconazole and an optical active body thereof and an intermediate. According to the method, a hydrazine compound and glyoxylic acid react to obtain a hydrazono acetic acid intermediate, and then the hydrazono acetic acid intermediate reacts with thiocyanate to obtain a prothioconazole target product. The reaction regioselectivity is good, few side products are generated, and the yield is high. The requirement for equipment is not high, and anhydrous and anaerobic operation is not needed. The process is simple, few three wastes are generated, and the method is suitable for industrial production.
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- Acyl-mercapto-triazolyl derivatives and the use thereof as microbicides
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PCT No. PCT/EP97/01997 Sec. 371 Date Oct. 27, 1998 Sec. 102(e) Date Oct. 27, 1998 PCT Filed Apr. 21, 1997 PCT Pub. No. WO97/42178 PCT Pub. Date Nov. 13, 1997The present invention provides the composition for novel acyl-mercapto-triazolyl derivatives, and the acid addition salts and metal salt complexes thereof; a process for their preparation; and a method for their use as microbicides.
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- Sulphonyl-mercapto-triazolyl derivatives and their use as microbicides
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PCT No. PCT/EP97/02408 Sec. 371 Date Nov. 19, 1998 Sec. 102(e) Date Nov. 19, 1998 PCT Filed May 12, 1997 PCT Pub. No. WO97/44332 PCT Pub. Date Nov. 27, 1997The present invention relates to novel sulphonyl-mercapto-triazolyl derivatives, their acid addition salts and metal salt complexes; a process for the preparation of the novel compounds; and a method for their use as microbicides.
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- Triazolyl-mercaptides and their use as microbicides
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PCT No. PCT/EP97/01996 Sec. 371 Date Oct. 23, 1998 Sec. 102(e) Date Oct. 23, 1998 PCT Filed Apr. 21, 1997 PCT Pub. No. WO97/41107 PCT Pub. Date Nov. 6, 1997Triazoyl mercaptides of the formula (I) in which M is an alkaline metal cation, an equivalent of an alkaline earth cation, an equivalent of a copper zinc, iron or nickel cation or an ammonium cation and R1 is various radicals, a process for the production of the novel substances and their use to combat undesired micro-organisms.
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- Triazolyl disulphides
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PCT No. PCT/EP97/02282 Sec. 371 Date Nov. 5, 1998 Sec. 102(e) Date Nov. 5, 1998 PCT Filed May 5, 1997 PCT Pub. No. WO97/43269 PCT Pub. Date Nov. 20, 1997The present invention provides the composition for novel triazolyl disulphides, the acid addition salts and metal salt complexes of the triazolyl disulphides, a process for their preparation, and a method for their use as microbicides.
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- Thiocyano- triazolyl derivatives and their use as microbicides
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PCT No. PCT/EP97/02373 Sec. 371 Date Nov. 17, 1998 Sec. 102(e) Date Nov. 17, 1998 PCT Filed May 9, 1997 PCT Pub. No. WO97/44331 PCT Pub. Date Nov. 27, 1997The present invention provides novel thiocyanato-triazolyl derivatives, and the acid addition salts and metal salt complexes thereof; a process for their preparation; and a method for their use as microbicides.
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- Triazolyl derivatives
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Triazolyl derivatives STR1 in which R1 and R2 are identical or different and represent optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aroxyalkyl, optionally substituted aryl or optionally substituted heteroaryl and X represents the groups --SH, --SR3, --SO--R3, --SO2 --R3 or --SO3 H, in which R3 represents alkyl which is optionally substituted by fluorine and/or chlorine, alkenyl which is optionally substituted by fluorine and/or chlorine, optionally substituted aralkyl or optionally substituted aryl, and their acid addition salts and metal salt complexes, a plurality of processes for the preparation of the new substances, and their use as microbicides in plant protection and materials protection.
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