cas 2520-36-7, Ficine | Articles data ｜lookchem

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2520-36-7

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Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases
The screening of the ICSN chemical library on various disease-relevant protein kinases led to the identification of natural flavonoidal alkaloids of unknown configuration as potent inhibitors of the CDK1 and CDK5 kinases. We thus developed an efficient and modular synthetic strategy for their preparation and that of analogues in order to determine the absolute configuration of the active natural flavonoidal alkaloids and to provide further insights on the structure-activity relationships in this series. The structural determinants of the interaction between some flavonoidal alkaloids with specific kinases were also evaluated using molecular modeling.
Nguyen, Thanh Binh,Lozach, Olivier,Surpateanu, Georgiana,Wang, Qian,Retailleau, Pascal,Iorga, Bogdan I.,Meijer, Laurent,Guéritte, Fran?oise
p. 2811 - 2819
(2012/06/01)

Synthesis of (+) ficine.
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Anjaneyulu,Govindachari
p. 2847 - 2848
(2007/10/10)

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1363338-97-9
ficine

Chemical Properties

Melting Point: 235 °C
Boiling Point: 517.7°C at 760 mmHg
Flash Point:266.9°C
Density: 1.345g/cm³
Vapor Pressure: 2.45E-11mmHg at 25°C
PKA: 5.89±0.40(Predicted)
PSA: 73.91000
LogP: 3.57580

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