2520-36-7

Basic information

• Product Name: Ficine
• Synonyms: Ficine;(-)-5,7-Dihydroxy-8-(1-methyl-2-pyrrolidinyl)flavone
• CAS NO: 2520-36-7
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.37
• Mol File: 2520-36-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 235 °C
• Boiling Point: 517.7°C at 760 mmHg
• Flash Point: 266.9°C
• Appearance: /
• Density: 1.345g/cm³
• Vapor Pressure: 2.45E-11mmHg at 25°C
• Refractive Index: 1.663
• PKA: 5.89±0.40(Predicted)
• CAS DataBase Reference: Ficine(CAS DataBase Reference)
• NIST Chemistry Reference: Ficine(2520-36-7)
• EPA Substance Registry System: Ficine(2520-36-7)

Safety Data

• Hazardous Substances Data: 2520-36-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H19NO4/c1-21-9-5-8-13(21)18-14(22)10-15(23)19-16(24)11-17(25-20(18)19)12-6-3-2-4-7-12/h2-4,6-7,10-11,13,22-23H,5,8-9H2,1H3

Upstream product

• 7225-08-3 2-hydroxy-1-methylpyrrolidine 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 2520-36-7 ficine 

Downstream Products

• 1363338-97-9 ficine 

Relevant articles and documents

Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases

The screening of the ICSN chemical library on various disease-relevant protein kinases led to the identification of natural flavonoidal alkaloids of unknown configuration as potent inhibitors of the CDK1 and CDK5 kinases. We thus developed an efficient and modular synthetic strategy for their preparation and that of analogues in order to determine the absolute configuration of the active natural flavonoidal alkaloids and to provide further insights on the structure-activity relationships in this series. The structural determinants of the interaction between some flavonoidal alkaloids with specific kinases were also evaluated using molecular modeling.