Name
|
|
EINECS
|
248-341-6
|
CAS No.
|
27220-47-9
|
Density
|
1.33 g/cm3
|
PSA
|
27.05000
|
LogP
|
5.80140
|
Solubility
|
0.37g/L(ambient temperature)
|
Melting Point
|
86.8 °C
|
Formula
|
C18H15Cl3N2O
|
Boiling Point
|
533.8 °C at 760 mmHg
|
Molecular Weight
|
381.689
|
Flash Point
|
276.6 °C
|
Transport Information
|
N/A
|
Appearance
|
N/A
|
Safety
|
24/25-36/37/39
|
Risk Codes
|
36/37/38
|
Molecular Structure
|
|
Hazard Symbols
|
Xi
|
Synonyms
|
Imidazole,1-[2,4-dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]-(8CI);1-[2,4-Dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]imidazole;NSC 187789;
|
Article Data |
3
|
Econazole Chemical Properties
Molecular Formula: C
18H
15Cl
3N
2O
Formula Weight: 381.68
mp: 86.8
°C
State: Solid
Predicted
WATER Solubility: 1.48e-03 mg/mL
Econazole Uses
Econazole is the first generation of products
Imidazole antifungal agents. It is used topically in dermatomycoses also orally and parenterally.
Econazole Production
10.3 in the α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 in
Sodium hydride 50 anhydrous tetrahydrofuran the slurry mixing returning 2h, when hydrogen reaction after successive accession 60 dimethyl formamide and 8-chloro-benzyl chloride to return 2h. Tetrahydrofuran pressure steam addition, the residues dumped into the
WATER with
Benzene extraction, extracts from decompression
Benzene, in econazole in the free base, and then concentrated nitric acid, generating econazole nitrate.
Econazole Toxicity Data With Reference
Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD50 values were found to be 462, 668, 272, and > 160 mg/kg, respectively.
Econazole Safety Profile
Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 24/25-36/37/39