Bulletin of the Chemical Society of Japan p. 3185 - 3188 (1986)
Update date:2022-08-03
Topics:
Sakai, Takashi
Nakamura, Toshiki
Fukuda, Katsuyoshi
Amano, Eiichiro
Utaka, Masanori
Takeda, Akira
Reduction of ethyl 2-acetoxy-3-oxobutanoate (4a) with immobilized baker's yeast in calcium alginate gel gave a 18:19:63 mixture of ethyl (2R,3S)- and (2S,3S)-2-acetoxy-3-hydroxybutanoates and ethyl (2S,3S)-2,3-dihydroxybutanoate each with >95percent e.e. in 58percent yield.A similar treatment of a 2-benzoyloxy analog of 4a afforded a 6:94 mixture of ethyl (2R,3S)- and (2S,3S)-2-benzoyloxybutanoates (>95percent e.e.) in 70percent yield.Their absolute configurations were determined by comparison with authentic (2R,3S)- and (2S,3S)-2,3-dihydroxybutanoic acids.Effects of the immobilization and the pH of culture solution on the product ratio are also discussed.
View MoreNingbo Hi-tech Zone Nice-Synth Chemical Industry Ltd.
Contact:+86-(574)-81110986
Address:No. 1210, Building 3, Wante Business Centre, Hi-tech Zone, Ningbo
HAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Contact:+86-574-87065746
Address:10th Floor, No.787 Baizhang East Road,
Contact:+86-025-52406782
Address:8 Taizishan Rd., Yanjiang Industrial Development Area, Nanjing, Jiangsu, China.
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd
Contact:0086-10-64430626
Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Doi:10.1039/c39860000777
(1986)Doi:10.1016/j.bmcl.2011.10.021
(2011)Doi:10.1021/ol049346v
(2004)Doi:10.1021/om010348i
(2001)Doi:10.1016/S0960-894X(03)00030-1
(2003)Doi:10.1021/jo01021a011
(1965)