Bioorganic and Medicinal Chemistry Letters p. 3671 - 3676 (1998)
Update date:2022-08-17
Topics:
Guzaev, Andrei
Manoharan, Muthiah
A novel method for the preparation of oligonucleotides conjugated with nucleophilic ligands is described. A new phosphoramidite building block derived from N-chloroacetyl-6-aminohexanol is attached at the 5'-terminus on the last step of oligonucleotide synthesis. Postsynthesis treatment of support-bound modified oligonucleotide with a variety of amines and mercaptans affords conjugates in high yield.
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