Journal of Organic Chemistry p. 854 - 859 (1993)
Update date:2022-08-11
Topics:
Phillips, Dennis R.
Uramoto, Masakazu
Isono, Kiyoshi
McCloskey, James A.
The structure of phosmidosine (1), a novel proline-containing nucleotide antibiotic from Streptomyces durhameusis, active against the pathogenic fungus Botrytis cinerea, was determined by mass spectrometry and NMR spectroscopy.Homologs 2, 3, and the isomer 4 were detected and characterized using approaches based principally on tandem mass spectrometry and combined liquid chromatography-mass spectrometry which permitted assignment of most structural features directly in the crude isolate without prior isolation of individual components.Conversion of 1-4 to the O-isopropylidene derivatives 1a-4a by a microscale procedure resulted in enhanced fast atom bombardment ionization (FAB) signal to background sensitivity.Collision-induced dissociation mass spectra were aquired from molecular ions and ion source-generated fragment ions and used in conjunction with FAB-deuterium exchange methods for the assignment of structural differences between 1a-4a.
View MoreContact:+86-513-80923002
Address:Suzhou Road 8,Beixin,Qidong,Jiangsu province,P.R.226221,China
Contact:86-21-57725962
Address:shanghai
Yangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Contact:+31-24-3886056
Address:Binderskampweg 29 Unit 36
website:http://www.china-sinoway.com
Contact:+86-592-5853819
Address:16/F,Huicheng Comm,Complex,No839 XiaHe Rd, Xiamen,China
Doi:10.1007/s11164-015-2169-0
(2016)Doi:10.1039/c6ra03065c
(2016)Doi:10.1080/00397919108016789
(1991)Doi:10.1134/S0036023617020152
(2017)Doi:10.1002/ejic.201900151
(2019)Doi:10.1007/s11696-019-00799-6
(2020)